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SPRED3 Knockout Cell Lines

Gene: SPRED3

Official Full Name: sprouty related EVH1 domain containing 3provided by HGNC

Gene Summary: This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13770 SPRED3 Knockout cell line (HEK293) Human SPRED3 1:3~1:6 Negative Online Inquiry
KO13771 SPRED3 Knockout cell line (A549) Human SPRED3 1:3~1:4 Negative Online Inquiry

Background

SPRED3 Gene Knockout Cell Lines are advanced cellular models designed specifically to investigate the role of the SPRED3 gene in various biological processes. SPRED3, a member of the Sprouty-related protein family, is known for its involvement in modulating growth factor signaling pathways, particularly those associated with the MAPK/ERK pathway. These knockout cell lines have been engineered to lack functional SPRED3, allowing researchers to study the consequences of its absence on cellular behavior and signaling dynamics.

The primary function of these cell lines is to facilitate the exploration of the specific mechanisms by which SPRED3 regulates cellular responses to external stimuli, particularly growth factors. By utilizing CRISPR-Cas9 or similar gene-editing technologies, these cell lines ensure precise and efficient targeting of the SPRED3 gene, resulting in a robust and reproducible model for scientific inquiry. Researchers can leverage these models to assess cellular proliferation, differentiation, and survival in both in vitro and preclinical in vivo settings.

The scientific importance of SPRED3 Gene Knockout Cell Lines extends to various applications, including cancer research, developmental biology, and the study of metabolic disorders. By elucidating SPRED3's role in signaling cascades, these cell lines provide valuable insights that can lead to the identification of novel therapeutic targets and biomarkers.

Compared to alternative models, SPRED3 Gene Knockout Cell Lines offer several unique advantages. They provide a clean genetic background that eliminates confounding factors present in traditional cell lines, ensuring experimental accuracy. Moreover, these knockout lines can be customized to different cellular contexts, enhancing the versatility of experimental designs.

For researchers and clinicians, this product is indispensable due to its ability to deepen our understanding of cellular signaling mechanisms and their implications in health and disease. The implications of such research are profound, potentially leading to breakthroughs in targeted therapies and personalized medicine.

Our company, renowned for its commitment to innovation in biological research tools, offers SPRED3 Gene Knockout Cell Lines as part of our comprehensive portfolio of high-quality cellular models, designed to empower researchers in their quest for scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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