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SPPL2A Knockout Cell Lines

Gene: SPPL2A

Official Full Name: signal peptide peptidase like 2Aprovided by HGNC

Gene Summary: This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24551 SPPL2A Knockout cell line (HeLa) Human SPPL2A 1:3~1:6 Negative Online Inquiry
KO24552 SPPL2A Knockout cell line (HCT 116) Human SPPL2A 1:2~1:4 Negative Online Inquiry
KO24553 SPPL2A Knockout cell line (HEK293) Human SPPL2A 1:3~1:6 Negative Online Inquiry
KO24554 SPPL2A Knockout cell line (A549) Human SPPL2A 1:3~1:4 Negative Online Inquiry

Background

SPPL2A Gene Knockout Cell Lines are specialized cellular models engineered to lack functional SPPL2A (Signal Peptide Peptidase-Like 2A). This product allows researchers to investigate the biological roles of SPPL2A in numerous physiological processes, including immune regulation and inflammation. By disabling this specific gene, the cell lines provide an invaluable tool for studying the consequences of SPPL2A deficiency on cellular pathways and responses.

Mechanistically, these knockout cell lines are designed to disrupt the normal function of SPPL2A, which is known to be involved in the cleavage and processing of select substrates in the endoplasmic reticulum, ultimately impacting various signaling cascades within the cell. By utilizing these knockout models, scientists can gain insights into the function of SPPL2A in cellular contexts, including its implications in disease mechanisms, especially in immunological disorders and certain cancers.

The scientific importance of SPPL2A Gene Knockout Cell Lines extends beyond basic research, offering applications in drug discovery, biomarker identification, and therapeutic development. Their use can facilitate the testing of drug candidates that target pathways influenced by SPPL2A, thereby accelerating the translation of laboratory findings into clinical practice.

Compared to traditional cell lines, these knockout models provide a precise genetic background that allows for a clearer interpretation of experimental results, enhancing reliability and reproducibility in research. Furthermore, they represent a streamlined way of generating data that could lead to novel therapeutic strategies or biomarkers for ongoing clinical challenges.

The value of SPPL2A Gene Knockout Cell Lines lies in their ability to enable researchers and clinicians to dissect complex biological pathways, leading to breakthroughs in understanding and treating diseases related to SPPL2A function. Our company prides itself on providing high-quality, rigorously characterized biological products, ensuring that researchers have access to reliable tools that support their innovative endeavors in advancing biological science.

Please note that all services are for research use only. Not intended for any clinical use.

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