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SEC31A Knockout Cell Lines

Gene: SEC31A

Official Full Name: SEC31 homolog A, COPII coat complex componentprovided by HGNC

Gene Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30234 SEC31A Knockout cell line (HeLa) Human SEC31A 1:3~1:6 Negative Online Inquiry
KO30235 SEC31A Knockout cell line (HCT 116) Human SEC31A 1:2~1:4 Negative Online Inquiry
KO30236 SEC31A Knockout cell line (HEK293) Human SEC31A 1:3~1:6 Negative Online Inquiry
KO30237 SEC31A Knockout cell line (A549) Human SEC31A 1:3~1:4 Negative Online Inquiry

Background

SEC31A Gene Knockout Cell Lines are genetically engineered cellular systems that have had the SEC31A gene disrupted or replaced, leading to the loss of its function. Sec31A is a crucial component of the COPII (coat protein complex II) complex, which is integral to the process of protein transport from the endoplasmic reticulum to the Golgi apparatus. By specifically targeting and eliminating the SEC31A gene, these cell lines provide critical insights into the mechanisms of vesicle formation and trafficking in eukaryotic cells.

The primary function of these knockout cell lines lies in their ability to facilitate the study of cellular processes such as protein secretion, cell signaling, and overall cellular homeostasis. Researchers can observe the effects of SEC31A depletion on intracellular transport dynamics and elucidate its role in various diseases, including cancer and neurodegenerative disorders. This allows for a better understanding of cellular dysfunctions that contribute to pathologies related to protein misfolding and trafficking anomalies.

From a scientific perspective, SEC31A Gene Knockout Cell Lines hold significant importance in both research and clinical settings. Novel therapeutic strategies can be developed from findings related to SEC31A, paving the way for targeted interventions in conditions linked to COPII dysfunction. This product stands out due to its precise genetic editing, enabling researchers to study specific knockout phenotypes without confounding variables, unlike traditional methods that may employ pharmacological inhibitors.

The unique selling points of these knockout cell lines include their validated genetic modification, reliability in experimental reproducibility, and the potential for high-throughput screening applications. These advantages make SEC31A Gene Knockout Cell Lines a valuable resource for researchers and clinicians seeking to dissect the role of the SEC31A protein and its impact on cellular physiology.

Our company specializes in providing advanced genetic models and biological products, underscoring our commitment to facilitating cutting-edge research. With an emphasis on scientific accuracy and innovation, we strive to support researchers in their quest for discovery and therapeutic advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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