Gene: SDC1
Official Full Name: syndecan 1provided by HGNC
Gene Summary: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09999 | SDC1 Knockout cell line (HeLa) | Human | SDC1 | 1:3~1:6 | Negative | Online Inquiry |
KO10000 | SDC1 Knockout cell line (HCT 116) | Human | SDC1 | 1:2~1:4 | Negative | Online Inquiry |
KO10001 | SDC1 Knockout cell line (HEK293) | Human | SDC1 | 1:3~1:6 | Negative | Online Inquiry |
KO10002 | SDC1 Knockout cell line (A549) | Human | SDC1 | 1:3~1:4 | Negative | Online Inquiry |
SDC1 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the Syndecan-1 (SDC1) gene, which encodes a critical proteoglycan involved in cell adhesion, proliferation, and extracellular matrix interactions. These cell lines provide a unique platform for studying the multifaceted roles of SDC1 in cellular processes, particularly its involvement in various cancer types, wound healing, and tissue regeneration.
The primary function of SDC1 is to act as a co-receptor that facilitates signaling pathways by binding to growth factors, cytokines, and extracellular matrix components. The knockout of this gene leads to profound alterations in cellular characteristics, such as changes in motility, adhesion properties, and responses to growth stimuli. By using SDC1 Gene Knockout Cell Lines, researchers can elucidate these mechanisms and assess the implications of SDC1 loss on cellular behavior and disease progression.
In terms of scientific importance, these cell lines serve as a valuable tool in both basic research and clinical applications. They allow for the exploration of SDC1's role in tumor microenvironments, its impact on immune cell interactions, and its involvement in metastasis. Moreover, the SDC1 knockout model can enhance the understanding of therapeutic responses and provide insights into SDC1-targeted therapies.
What sets these cell lines apart from traditional models is their specific genetic modification, which enables researchers to study the direct consequences of SDC1 absence without the confounding effects often associated with knockout approaches. Additionally, these cell lines are rigorously tested for consistency and reliability, ensuring that experiments yield reproducible and meaningful results.
For researchers and clinicians dedicated to advancing cancer biology, regenerative medicine, and cell signaling studies, SDC1 Gene Knockout Cell Lines represent a transformative resource. Their versatility and specificity make them essential for investigating the complexities of cell behavior in health and disease. Backed by our company’s commitment to delivering high-quality biological products and extensive experience in cell line development, we are poised to support cutting-edge research with innovative solutions tailored to the needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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