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RTCB Knockout Cell Lines

Gene: RTCB

Official Full Name: RNA 2',3'-cyclic phosphate and 5'-OH ligaseprovided by HGNC

Gene Summary: Enables RNA ligase (GTP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22471 RTCB Knockout cell line (HeLa) Human RTCB 1:3~1:6 Negative Online Inquiry
KO22472 RTCB Knockout cell line (HCT 116) Human RTCB 1:2~1:4 Negative Online Inquiry
KO22473 RTCB Knockout cell line (HEK293) Human RTCB 1:3~1:6 Negative Online Inquiry

Background

RTCB Gene Knockout Cell Lines are specialized cell lines that have been engineered to lack the RNA polymerase accessory subunit RTCB, a crucial factor involved in RNA biogenesis and processing. These knockout models provide significant insights into the functional dynamics of RNA pathways, allowing researchers to investigate the roles of RTCB in cellular processes such as transcription regulation, RNA maturation, and stress responses.

The key mechanism of these cell lines involves a deliberate disruption of the RTCB gene through advanced gene editing technologies such as CRISPR/Cas9. This targeted approach allows for precise elimination of RTCB, thereby promoting the investigation of its effects on cellular behavior, gene expression profiles, and overall cellular homeostasis. The ability to generate these knockouts facilitates comprehensive studies aimed at elucidating the molecular underpinnings of diseases linked to RNA dysregulation, such as various cancers and neurodegenerative disorders.

In research and clinical settings, RTCB Gene Knockout Cell Lines serve as a powerful tool for understanding gene function, validating gene targets for drug discovery, and assessing the efficacy of therapeutic agents aimed at altering RNA processing pathways. Their application spans various fields, including molecular biology, pharmacology, and genetics, making them invaluable in advancing our understanding of complex biological systems.

When compared to traditional knockout strategies, RTCB Gene Knockout Cell Lines offer the advantage of precise genomic modifications with minimal off-target effects, resulting in highly reproducible and reliable data. This ensures that researchers can draw accurate conclusions about the role of RTCB without confounding variables introduced by less specific methods.

The value of RTCB Gene Knockout Cell Lines is not only in their versatility for a wide range of applications but also in their capability to enhance research efficiency and depth. Researchers and clinicians alike can greatly benefit from these tools, as they provide insights that can lead to breakthroughs in treatment approaches for RNA-related diseases.

Our company prides itself on a robust background in biotechnological innovation, offering high-quality, ready-to-use biological products, including these specialized RTCB Gene Knockout Cell Lines. With our expertise, we are dedicated to empowering the scientific community in their quest for knowledge and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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