Gene: RNF6
Official Full Name: ring finger protein 6provided by HGNC
Gene Summary: The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35596 | RNF6 Knockout cell line (HeLa) | Human | RNF6 | 1:3~1:6 | Negative | Online Inquiry |
KO35597 | RNF6 Knockout cell line (HCT 116) | Human | RNF6 | 1:2~1:4 | Negative | Online Inquiry |
KO35598 | RNF6 Knockout cell line (HEK293) | Human | RNF6 | 1:3~1:6 | Negative | Online Inquiry |
KO35599 | RNF6 Knockout cell line (A549) | Human | RNF6 | 1:3~1:4 | Negative | Online Inquiry |
RNF6 Gene Knockout Cell Lines are genetically engineered models designed to facilitate the study of the RNF6 (Ring Finger Protein 6) gene, pivotal in numerous cellular processes, including transcription regulation, mitosis, and the ubiquitin-proteasome system. The RNF6 protein is an E3 ubiquitin ligase that plays an essential role in protein tagging for degradation, affecting key oncogenic pathways. By creating knockout cell lines, researchers can effectively silence the RNF6 gene, thus enabling a direct observation of downstream effects and giving deeper insights into its biological roles.
The mechanism through which these knockout cell lines operate is rooted in CRISPR-Cas9 gene editing technology. This powerful tool allows for precise alterations to the genome, ensuring that the RNF6 target gene is deleted or disrupted. The resulting cell lines serve as critical tools for understanding the functional implications of RNF6 loss, providing a robust platform for studying its involvement in cancer, neurodevelopmental disorders, and other pathologies.
In the realm of scientific research and clinical applications, RNF6 Gene Knockout Cell Lines are invaluable. They provide cutting-edge models that support advanced studies in gene function, drug responses, and therapeutic interventions. As RNF6 is implicated in various cancers, these models enable researchers to evaluate potential treatments and develop targeted therapies more efficiently than traditional methods.
What sets our RNF6 Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency, with extensive validation ensuring reliable performance. Additionally, unlike generic knockout models, our cell lines come with detailed characterizations and customer support to assist researchers in optimizing their studies.
For researchers and clinicians striving for innovation and precision in their work, the RNF6 Gene Knockout Cell Lines represent a significant asset. They not only enhance understanding of complex biological systems but also pave the way for groundbreaking discoveries in disease research and treatment.
Our company's commitment to excellence in producing high-quality biological products underscores our dedication to advancing scientific knowledge and supporting the research community. Distributed with a focus on reliability and user-centric design, we strive to equip you with the tools necessary for success in your investigative endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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