Gene: RCN1
Official Full Name: reticulocalbin 1provided by HGNC
Gene Summary: Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35663 | RCN1 Knockout cell line (HeLa) | Human | RCN1 | 1:3~1:6 | Negative | Online Inquiry |
KO35664 | RCN1 Knockout cell line (HCT 116) | Human | RCN1 | 1:2~1:4 | Negative | Online Inquiry |
KO35665 | RCN1 Knockout cell line (HEK293) | Human | RCN1 | 1:3~1:6 | Negative | Online Inquiry |
KO35666 | RCN1 Knockout cell line (A549) | Human | RCN1 | 1:3~1:4 | Negative | Online Inquiry |
RCN1 Gene Knockout Cell Lines are precisely engineered cellular models created through advanced CRISPR/Cas9 gene-editing technology to specifically disrupt the RCN1 gene, which encodes for the protein reticulocalbin 1. These cell lines allow researchers to investigate the biological roles and molecular mechanisms of RCN1 in various cellular processes, such as calcium signaling, protein folding, and endoplasmic reticulum stress response.
Key mechanisms of these knockout cell lines involve the complete absence of the RCN1 protein, which enables researchers to elucidate downstream effects and compensatory pathways that may arise from its loss. This functional model is critical in studying the ramifications of RCN1 disruption on cellular metabolism, proliferation, and apoptosis, paving the way for more profound insights into diseases where RCN1 is implicated, such as neurological disorders and cancers.
Despite the availability of alternative cell lines, RCN1 Gene Knockout Cell Lines stand out for their rigorously validated knockout status, ensuring high specificity and reliability in experimental outcomes. Their use facilitates the exploration of novel therapeutic targets and biomarker identification, effectively advancing both fundamental research and potential clinical applications. They provide a crucial tool for drug discovery and developmental biology, thus serving to bridge the gap between laboratory findings and clinical interventions.
For researchers, clinicians, and pharmaceutical developers, the RCN1 Gene Knockout Cell Lines present an invaluable asset in the quest for innovative solutions to pressing biological questions and health challenges. Our company prides itself on offering cutting-edge biological tools backed by extensive expertise in genetic engineering, delivering products that expand research capabilities and enhance the understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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