Gene: RARG
Official Full Name: retinoic acid receptor gammaprovided by HGNC
Gene Summary: This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04233 | RARG Knockout cell line (HeLa) | Human | RARG | 1:3~1:6 | Negative | Online Inquiry |
KO04234 | RARG Knockout cell line (HCT 116) | Human | RARG | 1:2~1:4 | Negative | Online Inquiry |
KO04235 | RARG Knockout cell line (HEK293) | Human | RARG | 1:3~1:6 | Negative | Online Inquiry |
KO04236 | RARG Knockout cell line (A549) | Human | RARG | 1:3~1:4 | Negative | Online Inquiry |
RARG Gene Knockout Cell Lines are specialized cellular models designed to study the functional implications of the Retinoic Acid Receptor Gamma (RARG) gene. These engineered cell lines have undergone precise genomic alterations to permanently disrupt RARG expression, allowing researchers to elucidate the role of this nuclear receptor in cellular pathways, development, and disease processes. By facilitating the examination of RARG's influence on gene regulation and signaling pathways, these knockout cell lines provide invaluable tools for advancing our understanding of retinoid biology.
The primary function of RARG is to mediate the effects of retinoic acid, a critical molecule in cellular differentiation, proliferation, and apoptosis. The knockout of RARG allows for the identification of downstream targets and interactions with other signaling pathways, shedding light on its contribution to both normal physiological processes and pathologies such as cancer and metabolic disorders. By utilizing these knockout lines, researchers can experimentally manipulate and observe the consequences of RARG absence, paving the way for potential therapeutic strategies.
Scientifically, RARG Gene Knockout Cell Lines are essential for researchers aiming to explore the intricate roles of retinoic acid signaling in various contexts, including embryonic development, immune responses, and tumor progression. Their applications extend into drug discovery, molecular biology studies, and the development of targeted therapies, making them a staple in both academic and clinical research settings.
One of the unique advantages of our RARG Gene Knockout Cell Lines lies in their rigorously validated knockout efficiency and reproducibility, surpassing alternatives that often suffer from incomplete gene disruption or variability. Unlike transient knockdown systems, these stable lines provide consistent results over extended periods, thus empowering researchers to conduct longitudinal studies without the need for repeated transfections or treatments.
For researchers and clinicians alike, investing in RARG Gene Knockout Cell Lines is crucial for driving breakthrough discoveries in retinoic acid biology. The insights gained from using these cell lines could lead to novel therapeutic approaches for diseases linked to RARG dysfunction. Our company specializes in providing high-quality biological products, and our RARG Gene Knockout Cell Lines are developed with expert precision, ensuring that our customers have the most reliable tools at their disposal to advance their research and clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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