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QRFP Knockout Cell Lines

Gene: QRFP

Official Full Name: pyroglutamylated RFamide peptideprovided by HGNC

Gene Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14767 QRFP Knockout cell line (HeLa) Human QRFP 1:3~1:6 Negative Online Inquiry
KO14768 QRFP Knockout cell line (HCT 116) Human QRFP 1:2~1:4 Negative Online Inquiry

Background

QRFP Gene Knockout Cell Lines are meticulously engineered cellular models designed to study the function of the neuropeptide QRFP (quality control factor-1) gene. Through advanced CRISPR/Cas9 genome-editing technology, these cell lines have been created to provide vital insights into the role of QRFP in cellular signaling pathways, metabolic regulation, and behavior. By completely disrupting the QRFP gene, researchers can investigate downstream effects on neuropeptide signaling cascades and elucidate their implications in various physiological processes.

The primary function of QRFP is its involvement in the modulation of energy homeostasis and appetite regulation, positioning it as a critical target for understanding metabolic disorders like obesity and diabetes. These knockout cell lines facilitate the exploration of QRFP's influence on neurotransmitter release, behavioral responses, and hormonal regulation, which are crucial to advancing our comprehension of these complex systems.

The significance of QRFP Gene Knockout Cell Lines extends to both research and clinical settings, serving as indispensable tools for pharmacological studies and the development of novel therapeutic interventions. Their applications range from the evaluation of drug candidates targeting metabolic pathways to the in-depth study of neuroendocrine function. Compared to conventional cell lines, these knockout lines offer the unique advantage of greater specificity and relevance in modeling QRFP-related pathophysiology, enabling researchers to draw more accurate conclusions.

This product stands out due to its rigorous validation and greater reliability, ensuring that users will obtain replicable and interpretable results in their experiments. For researchers and clinicians interested in unpacking the complexities of neuropeptide signaling and its metabolic consequences, QRFP Gene Knockout Cell Lines represent a valuable and necessary asset in their scientific toolkit.

Our company specializes in cutting-edge biotechnology solutions, and we are committed to empowering the scientific community with high-quality biological products that drive discovery and innovation. With the introduction of QRFP Gene Knockout Cell Lines, we aim to support transformative research that enhances our understanding of neurophysiological mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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