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PHIP Knockout Cell Lines

Gene: PHIP

Official Full Name: PHIP subunit of CUL4-Ring ligase complexprovided by HGNC

Gene Summary: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15179 PHIP Knockout cell line (HeLa) Human PHIP 1:3~1:6 Negative Online Inquiry
KO15180 PHIP Knockout cell line (HCT 116) Human PHIP 1:2~1:4 Negative Online Inquiry
KO15181 PHIP Knockout cell line (HEK293) Human PHIP 1:3~1:6 Negative Online Inquiry
KO15182 PHIP Knockout cell line (A549) Human PHIP 1:3~1:4 Negative Online Inquiry

Background

PHIP Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology designed to facilitate the study of gene function and regulation through the targeted disruption of the PHIP gene. This innovative product utilizes CRISPR-Cas9 technology to create a precise knockout of the PHIP gene, enabling researchers to explore its involvement in various biological processes such as cellular signaling, metabolic regulation, and potential roles in disease states, including cancer and metabolic disorders.

The key mechanism of action relies on the delivery of a Cas9 nuclease and guide RNA that specifically binds to the PHIP gene sequence. This targeted approach leads to double-strand breaks, which are subsequently repaired by the cell’s homology-directed repair or non-homologous end joining pathways, resulting in a functional knockout of the gene. By utilizing these cell lines, researchers can better understand the consequences of gene disruption at both molecular and phenotypic levels, providing invaluable insights into therapeutic targets.

Scientifically, PHIP Gene Knockout Cell Lines are of paramount importance in both research and clinical applications. They serve as powerful models for studying gene function, elucidating disease mechanisms, and screening for new drugs. Their applications extend to oncology, metabolism, and developmental biology, making them essential tools for both academic and pharmaceutical research settings.

What sets our PHIP Gene Knockout Cell Lines apart from alternatives is the validation process and the precision of the gene editing. Each line is extensively characterized to ensure a complete knockout and maintain cellular integrity, providing researchers with confidence in their experimental outcomes. Additionally, our cell lines have been optimized for high reproducibility and consistent performance across different experimental conditions.

For researchers and clinicians, the value provided by PHIP Gene Knockout Cell Lines lies in their capacity to dramatically accelerate the discovery process while minimizing the uncertainties often associated with generic models. By enabling targeted research into specific gene functions with a high degree of confidence, our product facilitates innovative strategies for addressing complex biological questions.

As a leader in the field of biological products, our company prides itself on providing high-quality, meticulously validated genetic tools that empower the scientific community to advance their research effectively and efficiently.

Please note that all services are for research use only. Not intended for any clinical use.

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