Home / PCM1 Knockout Cell Lines

PCM1 Knockout Cell Lines

Gene: PCM1

Official Full Name: pericentriolar material 1provided by HGNC

Gene Summary: The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00263 PCM1 Knockout cell line (A549) Human PCM1 1:3~1:4 Negative Online Inquiry
KO04434 PCM1 Knockout cell line (HeLa) Human PCM1 1:3~1:6 Negative Online Inquiry
KO04435 PCM1 Knockout cell line (HCT 116) Human PCM1 1:2~1:4 Negative Online Inquiry
KO04436 PCM1 Knockout cell line (HEK293) Human PCM1 1:3~1:6 Negative Online Inquiry

Background

PCM1 Gene Knockout Cell Lines are specially engineered cellular models that have undergone precise gene editing to eliminate the expression of the PCM1 gene, which is implicated in critical cellular processes including centrosome organization and cell division. By utilizing advanced CRISPR/Cas9 technology, these knockout cell lines provide a valuable platform for studying the functional impacts of PCM1 depletion on various cellular mechanisms. Researchers can explore its role in diseases such as cancer, where dysregulation of centrosome dynamics may contribute to tumorigenesis.

The primary functions of PCM1 involve its participation in the assembly and maintenance of centrosomes, which are essential for proper cell cycle progression and cytokinesis. By knocking out the PCM1 gene, scientists can observe resultant phenotypes in cellular morphology, proliferation rates, and mitotic accuracy. This allows for in-depth investigations into the mechanistic pathways that lead to centrosome-related disorders, thus positioning PCM1 as a critical target in understanding and potentially treating such conditions.

The scientific importance of PCM1 Gene Knockout Cell Lines lies in their potential application in both fundamental research and translational medicine. These models can assist in drug discovery efforts aimed at targeting centriole biogenesis and cellular stability, enabling the development of novel therapeutic strategies. Furthermore, the insights gained from experiments utilizing these cell lines can pave the way for identifying biomarkers for centrosome dysregulation in various diseases.

Unlike available alternatives, PCM1 Gene Knockout Cell Lines offer unparalleled specificity and reliability thanks to their precision editing, leading to consistent experimental outcomes. Researchers can trust in the reproducibility of results, an essential factor when investigating complex biological processes.

The value of PCM1 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to facilitate groundbreaking discoveries that can ultimately inform treatment pathways and enhance our understanding of cellular dynamics in health and disease. With a commitment to innovation and quality, our company specializes in providing precise biological products tailored for high-impact research, ready to support scientists in their quest for knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.