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PAXIP1 Knockout Cell Lines

Gene: PAXIP1

Official Full Name: PAX interacting protein 1provided by HGNC

Gene Summary: This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30081 PAXIP1 Knockout cell line (HeLa) Human PAXIP1 1:3~1:6 Negative Online Inquiry
KO30082 PAXIP1 Knockout cell line (HCT 116) Human PAXIP1 1:2~1:4 Negative Online Inquiry
KO30083 PAXIP1 Knockout cell line (HEK293) Human PAXIP1 1:3~1:6 Negative Online Inquiry
KO30084 PAXIP1 Knockout cell line (A549) Human PAXIP1 1:3~1:4 Negative Online Inquiry

Background

PAXIP1 Gene Knockout Cell Lines are genetically engineered cell lines in which the PAXIP1 (PAX Interacting Protein 1) gene has been systematically disrupted, allowing for in-depth investigation into the gene's function and associated biological pathways. The PAXIP1 protein is implicated in key cellular processes such as transcription regulation, DNA repair, and cellular response to DNA damage, making these knockout cell lines invaluable for studying its role in various disease states, including cancers and neurodegenerative disorders.

These cell lines operate through the precise removal of the PAXIP1 coding sequence, resulting in a lack of functional protein expression. This disruption provides researchers with a unique model to observe the biological consequences of absent PAXIP1 activity, enabling comprehensive analyses of downstream effects on cell viability, proliferation, and response to treatments. By utilizing these engineered cell lines, researchers can dissect critical cell signaling pathways and better understand the molecular mechanisms behind pathologies linked to PAXIP1.

The scientific importance of PAXIP1 Gene Knockout Cell Lines lies in their applicability across diverse research areas, including oncology, pharmacology, and genetics. They can serve as powerful tools for drug discovery, offering insights into therapeutic targets and potential interventions for PAXIP1-associated disorders. Compared to conventional cell lines, which may have intact PAXIP1 function, these knockout models allow for a clearer understanding of causative relationships under controlled conditions.

Unique advantages of PAXIP1 Gene Knockout Cell Lines include their potential for high reproducibility in experimental setups and their compatibility with various high-throughput screening methods. This innovative product offers researchers an unparalleled resource to validate hypotheses and accelerate discoveries in the cellular mechanisms influenced by PAXIP1 disruptions.

In conclusion, PAXIP1 Gene Knockout Cell Lines are essential for advancing our understanding of critical biological processes and disease pathways, making them a valuable addition to any research laboratory focused on cellular biology, cancer research, and gene function studies. Our company, known for its cutting-edge biotechnological innovations and expertise in genetic engineering, is proud to offer these specialized cell lines to empower scientists in their quest for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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