Gene: PAX8
Official Full Name: paired box 8provided by HGNC
Gene Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34429 | PAX8 Knockout cell line (HCT 116) | Human | PAX8 | 1:2~1:4 | Negative | Online Inquiry |
PAX8 Gene Knockout Cell Lines are sophisticated cellular models designed to facilitate the study of the PAX8 gene, which is critically involved in the development of various tissues and has implications in numerous diseases, particularly cancer. This product is developed through advanced CRISPR/Cas9 genetic editing technology, ensuring precise knockout of the PAX8 gene in specific cell lines, thereby providing researchers with invaluable tools for functional genomics and disease modeling.
The main mechanism underlying PAX8 Gene Knockout Cell Lines is the establishment of targeted genetic disruptions, resulting in a loss of PAX8 expression. This enables researchers to elucidate the gene's function, assess its role in cellular processes such as differentiation and proliferation, and explore its involvement in pathology. By providing a tool to study the consequences of PAX8 gene loss, these cell lines are especially significant in research areas focused on thyroid neoplasia and other disorders where PAX8 has been implicated.
In both research and clinical settings, the ability to study gene function and disease mechanisms is paramount. PAX8 Gene Knockout Cell Lines offer unique advantages over traditional models, including their ability to mimic human disease conditions more accurately and their ease of use for high-throughput screening applications. The precision of CRISPR technology also mitigates off-target effects common with earlier gene editing methods, leading to more reliable and reproducible data.
Researchers and clinicians will find PAX8 Gene Knockout Cell Lines invaluable for advancing their studies in cancer biology, therapeutics, and genetics. The opportunity to utilize these models can significantly enhance understanding of PAX8’s role in cellular mechanisms, paving the way for novel treatment strategies.
Our company prides itself on its expertise in genetic engineering and commitment to providing high-quality biological products. With a catalog that includes a wide range of knockout cell lines and related genetic tools, we are dedicated to supporting the scientific community in making groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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