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NRG4 Knockout Cell Lines

Gene: NRG4

Official Full Name: neuregulin 4provided by HGNC

Gene Summary: The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24024 NRG4 Knockout cell line (HeLa) Human NRG4 1:3~1:6 Negative Online Inquiry
KO24025 NRG4 Knockout cell line (HCT 116) Human NRG4 1:2~1:4 Negative Online Inquiry
KO24026 NRG4 Knockout cell line (A549) Human NRG4 1:3~1:4 Negative Online Inquiry

Background

NRG4 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the neuromedin U and its impact on various biological processes. These cell lines have been genetically modified to disrupt the NRG4 gene, thereby providing a unique platform for researchers to investigate its functions in cellular signaling pathways, metabolic regulation, and potential links to disease states.

The primary function of NRG4 is its role as a regulator of energy homeostasis and glucose metabolism. By employing gene knockout technology, these cell lines create a controlled environment to dissect the molecular mechanisms underlying NRG4’s regulatory functions. Researchers can utilize these models to study alterations in cell signaling, gene expression profiles, and the physiological consequences of NRG4 deficiency, yielding insights into obesity, diabetes, and other metabolic disorders.

The scientific importance of NRG4 Gene Knockout Cell Lines lies in their application in mechanistic studies and drug development. They serve as crucial tools in preclinical research designed to screen novel therapeutics aimed at modulating NRG4 pathways, potentially offering new strategies for treating metabolic diseases. Furthermore, these unique cell lines can facilitate the development of personalized medicine approaches by identifying patient-specific NRG4 mutations and their implications.

What sets NRG4 Gene Knockout Cell Lines apart from other cellular models is their precision-engineered nature, allowing for reproducible and reliable experimental results. Unlike conventional cell lines that may still express the target gene, our knockout lines provide a definitive tool for studying the absence of NRG4 function with minimal genetic variability.

This product holds significant value for researchers and clinicians seeking to deepen their understanding of metabolic diseases and explore innovative therapeutic avenues. By using NRG4 Gene Knockout Cell Lines, users can generate more accurate and relevant data, ultimately leading to breakthroughs in treatment strategies.

Our company emphasizes a commitment to excellence in developing high-quality biological products designed to meet the evolving needs of the scientific community. With a focus on innovation and user support, we equip researchers with the necessary tools to advance their work effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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