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MTMR12 Knockout Cell Lines

Gene: MTMR12

Official Full Name: myotubularin related protein 12provided by HGNC

Gene Summary: Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21624 MTMR12 Knockout cell line (HeLa) Human MTMR12 1:3~1:6 Negative Online Inquiry
KO21625 MTMR12 Knockout cell line (HCT 116) Human MTMR12 1:2~1:4 Negative Online Inquiry
KO21626 MTMR12 Knockout cell line (HEK293) Human MTMR12 1:3~1:6 Negative Online Inquiry
KO21627 MTMR12 Knockout cell line (A549) Human MTMR12 1:3~1:4 Negative Online Inquiry

Background

MTMR12 Gene Knockout Cell Lines are specialized cellular models engineered to lack the MTMR12 gene, which plays a critical role in phosphoinositide metabolism and intracellular signaling pathways. These knockout lines serve as powerful tools for investigating the biological functions attributed to MTMR12 and its involvement in various cellular processes, including autophagy, apoptosis, and membrane trafficking.

The key mechanism underlying the functionality of these knockout cell lines lies in the targeted disruption of the MTMR12 gene. Utilizing state-of-the-art CRISPR-Cas9 technology, researchers can study the phenotypic changes resulting from the loss of MTMR12 expression, providing insights into its role in cellular homeostasis and disease states. This mechanism allows for a clearer understanding of the paths that lead to potential therapeutic targets, especially in the context of cancer and neurodegenerative diseases where MTMR12 has shown relevance.

The scientific importance of MTMR12 Gene Knockout Cell Lines is underscored by their diverse applications in fundamental research and biomedical discovery. They can be leveraged in studies exploring cellular signaling pathways, drug development, and toxicity screening, thereby advancing our knowledge of metabolic disorders. Additionally, their use in preclinical models can bridge the gap between laboratory findings and clinical applications.

Compared to traditional cell lines, MTMR12 Gene Knockout Cell Lines offer unique advantages, including precise gene editing, greater reliability in experimental reproducibility, and the ability to observe the entire spectrum of phenotypic variability due to gene deletion. These advantages render them invaluable to researchers and clinicians aiming to identify novel treatments or diagnostic markers.

For researchers focused on elucidating the pathways related to MTMR12 in health and disease, these knockout cell lines present an exceptional value proposition. Our company, with extensive expertise in genetic engineering and cellular models, is dedicated to delivering high-quality biological tools that facilitate cutting-edge research and foster innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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