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MTHFD1L Knockout Cell Lines

Gene: MTHFD1L

Official Full Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by HGNC

Gene Summary: The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04852 MTHFD1L Knockout cell line (HeLa) Human MTHFD1L 1:3~1:6 Negative Online Inquiry
KO04853 MTHFD1L Knockout cell line (HCT 116) Human MTHFD1L 1:2~1:4 Negative Online Inquiry
KO04854 MTHFD1L Knockout cell line (HEK293) Human MTHFD1L 1:3~1:6 Negative Online Inquiry
KO04855 MTHFD1L Knockout cell line (A549) Human MTHFD1L 1:3~1:4 Negative Online Inquiry

Background

MTHFD1L Gene Knockout Cell Lines are specifically engineered cellular models designed for the study of MTHFD1L, a critical enzyme involved in folate metabolism and cellular methylation processes. By utilizing CRISPR-Cas9 technology, these cell lines have been meticulously developed to disable the MTHFD1L gene, thereby enabling researchers to investigate the functional consequences of MTHFD1L deficiency. This knockout mechanism allows for the exploration of various biological pathways, facilitating insights into the enzyme's role in cellular proliferation, differentiation, and metabolic regulation.

The MTHFD1L enzyme is pivotal in the one-carbon metabolism pathway, contributing to the synthesis of purines and methionine, which are essential for DNA and RNA synthesis, and methylation reactions. By employing these knockout cell lines, researchers can dissect the biochemical pathways that MTHFD1L influences and gain a deeper understanding of its impact on human diseases, including cancer and metabolic disorders. Such insights are invaluable in both basic research and drug development, offering a potential avenue for therapeutic targets.

One of the significant advantages of using MTHFD1L Gene Knockout Cell Lines is their specificity and reliability, providing a controlled environment in which to analyze gene function without the confounding effects of other genes. Unlike alternative methods that involve pharmacological inhibition or transient knockdown techniques, these stable knockout lines offer consistent and reproducible results, making them a trustworthy choice for long-term studies.

For researchers and clinicians alike, the utility of MTHFD1L Gene Knockout Cell Lines extends beyond mere investigation; they can serve as an essential tool for developing novel therapeutic strategies and enhancing our understanding of metabolic pathways related to human health. By leveraging these models, users can significantly advance their research initiatives, potentially leading to breakthroughs in personalized medicine and targeted therapies.

At the forefront of biotechnological advancement, our company prides itself on its expertise in gene editing and cell line development, ensuring that researchers have access to high-quality, rigorously validated models like the MTHFD1L Gene Knockout Cell Lines to enhance scientific inquiry and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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