Gene: MBP
Official Full Name: myelin basic proteinprovided by HGNC
Gene Summary: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02556 | MBP Knockout cell line (HeLa) | Human | MBP | 1:3~1:6 | Negative | Online Inquiry |
KO02557 | MBP Knockout cell line (HCT 116) | Human | MBP | 1:2~1:4 | Negative | Online Inquiry |
KO02558 | MBP Knockout cell line (HEK293) | Human | MBP | 1:3~1:6 | Negative | Online Inquiry |
KO02559 | MBP Knockout cell line (A549) | Human | MBP | 1:3~1:4 | Negative | Online Inquiry |
MBP Gene Knockout Cell Lines are a revolutionary tool designed for researchers investigating the functions of the Myelin Basic Protein (MBP) gene, which plays a crucial role in the development and maintenance of myelin sheaths in the central nervous system. These cell lines have been engineered using advanced CRISPR-Cas9 technology to create precise gene knockouts, selectively disrupting the MBP gene's expression. This targeted approach allows for the examination of the cellular and molecular mechanisms underlying myelination and demyelination processes, providing insights into various neurological disorders such as multiple sclerosis.
The key functionality of MBP Gene Knockout Cell Lines lies in their ability to facilitate the study of gene function in a controlled environment. By removing the MBP gene, researchers can closely analyze the resultant phenotypic changes, signaling pathways, and molecular interactions without the interference of the MBP protein. This will enable the exploration of alternative myelin-related genes and proteins, potentially identifying new therapeutic targets for demyelinating diseases.
Scientifically, the importance of MBP Gene Knockout Cell Lines cannot be overstated; they represent a critical resource for both fundamental research and clinical applications. Researchers can utilize these lines for drug screening and developmental studies aimed at remyelination strategies, providing valuable data to advance treatment options for patients with demyelinating conditions.
What sets our MBP Gene Knockout Cell Lines apart from alternative products on the market is their superior quality and reliability. Developed by a team of experienced scientists, these cell lines are rigorously validated to ensure consistent performance, allowing for reproducibility in experimental outcomes. Moreover, our comprehensive support, including user guides and troubleshooting assistance, ensures that researchers can maximize their investment in these cell lines.
In the ever-evolving landscape of neurological research, MBP Gene Knockout Cell Lines offer a powerful tool for unlocking new scientific discoveries. By choosing our product, researchers and clinicians gain access to top-tier resources backed by the expertise and commitment of our company, which specializes in cutting-edge biological research products.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.