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LRRC4B Knockout Cell Lines

Gene: LRRC4B

Official Full Name: leucine rich repeat containing 4Bprovided by HGNC

Gene Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse assembly and synaptic membrane adhesion. Predicted to be located in cerebellar mossy fiber and presynaptic membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22101 LRRC4B Knockout cell line (HEK293) Human LRRC4B 1:3~1:6 Negative Online Inquiry

Background

LRRC4B Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene editing to disrupt the LRRC4B gene, which is known to play a critical role in synaptic functioning and neuronal signal transmission. These cell lines provide researchers with a unique tool to investigate the implications of LRRC4B deficiency in various biological processes, such as neurodevelopmental disorders, synaptic plasticity, and potential neurodegenerative diseases. By creating a controlled environment where the LRRC4B gene is nonfunctional, scientists can study the resultant phenotypic changes and elucidate the gene’s biological significance.

The functionality of LRRC4B Gene Knockout Cell Lines lies in their ability to mirror the specific biological alterations that occur in vivo when the LRRC4B gene is absent. This mechanism allows for the dissection of molecular pathways and cellular interactions that are otherwise difficult to study in complex organisms. In experimental setups, researchers can assess changes in synaptic efficiency, receptor localization, and overall neuronal behavior, thereby contributing to a deeper understanding of the gene’s role in health and disease.

In terms of scientific importance, these cell lines are invaluable in both research and clinical settings. They facilitate the discovery of novel therapeutic targets and biomarkers that could lead to advancements in treatment strategies for conditions such as autism spectrum disorders and schizophrenia. The utility of LRRC4B knockout models extends to drug screening and the evaluation of neuroprotective compounds, where results from these models may influence clinical decision-making.

Compared to alternative cell lines that may retain functional LRRC4B, our LRRC4B Gene Knockout Cell Lines offer a definitive model devoid of the gene’s influence, ensuring specific and controlled experimental conditions. By providing precise genetic editing, we reduce the variability often seen in classical knockdown approaches, enhancing reproducibility and reliability of experimental outcomes.

For researchers and clinicians seeking to advance their understanding of synaptic biology and neurodevelopment, the LRRC4B Gene Knockout Cell Lines present a robust and innovative solution. Our commitment to developing high-quality, accurately characterized biological products underscores our expertise in the field, ensuring that our offerings not only meet but exceed the expectations of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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