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KRT9 Knockout Cell Lines

Gene: KRT9

Official Full Name: keratin 9provided by HGNC

Gene Summary: This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07055 KRT9 Knockout cell line (HeLa) Human KRT9 1:3~1:6 Negative Online Inquiry

Background

KRT9 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the study of keratin gene functions, specifically the KRT9 gene, which encodes a type of keratin vital for the structural integrity of the epithelial cells in the skin and other tissues. These cell lines are created through advanced CRISPR-Cas9 gene-editing technology, allowing for precise eliminations of the KRT9 gene. The resulting knockout models are instrumental in elucidating the role of KRT9 in cellular processes such as differentiation, proliferation, and response to mechanical stress.

The key mechanism underlying the functionality of KRT9 Gene Knockout Cell Lines lies in their ability to mimic specific pathological conditions, including skin disorders and keratinization defects, by studying changes in cellular morphology, signaling pathways, and gene expression profiles upon the loss of KRT9 function. Additionally, these models serve as valuable tools in pharmacological research, enabling the assessment of drug efficacy and toxicity, which is vital for translational studies aimed at developing new therapeutic strategies.

In research and clinical settings, the KRT9 Gene Knockout Cell Lines hold significant scientific importance as they provide a robust framework to investigate dermatological diseases, regenerative medicine applications, and keratinocyte biology. Compared to traditional methods, these knockout lines offer enhanced specificity, reproducibility, and the ability to conduct high-throughput screening, making them a superior choice for researchers.

The unique selling points of the KRT9 Gene Knockout Cell Lines lie in their design, which not only ensures high efficiency in gene editing but also maintains the cellular morphology and functionality typically exhibited by wild-type keratinocytes. Researchers and clinicians can leverage these models to make meaningful advancements in understanding keratin dynamics and developing innovative treatments for skin-related conditions.

Our company specializes in producing high-fidelity biological tools tailored for cutting-edge research. We are committed to supporting the scientific community by providing top-tier products like the KRT9 Gene Knockout Cell Lines, promoting innovative research and improving patient outcomes through rigorous scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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