Gene: KLRK1
Official Full Name: killer cell lectin like receptor K1provided by HGNC
Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09980 | KLRK1 Knockout cell line (HCT 116) | Human | KLRK1 | 1:2~1:4 | Negative | Online Inquiry |
KLRK1 Gene Knockout Cell Lines represent a groundbreaking resource in molecular biology, specifically engineered to eliminate the expression of the KLRK1 gene, which encodes the NKG2D receptor associated with immune regulation and stress responses. These knockout cell lines serve as a powerful tool for researchers studying the mechanisms of immune activation, tumor evasion, and the complexities of cell-mediated cytotoxicity. By removing KLRK1 functionality, scientists can investigate pathways and interactions that define immune cell behavior without the influence of this critical receptor.
The primary function of KLRK1 Gene Knockout Cell Lines lies in their ability to facilitate detailed studies of natural killer (NK) and T cell responses, offering insights into how cancer cells evade immune detection. By utilizing these knockout lines, researchers can elucidate the roles of NKG2D and its ligands, as well as the broader implications for developing therapeutic strategies against malignancies and autoimmune diseases. The absence of KLRK1 enables a clear observation of how immune responses are modulated in varying conditions, providing a tactical advantage in preclinical research.
The scientific community values these cell lines for their applications in immunology, cancer biology, and therapeutic development. Their unique advantage is rooted in the specificity of the knockout, which allows for more accurate modeling of human physiological responses compared to existing alternatives that may display heterogeneous gene expression. This specificity enhances the reliability and reproducibility of experimental results, making KLRK1 knockout cell lines indispensable for elucidating immune dynamics.
Researchers and clinicians benefit from these cell lines as they promote a deeper understanding of immune interactions, which is critical for advancing cellular therapies and immunotherapeutics. Moreover, this innovative product aligns with emerging trends in personalized medicine by providing a platform for tailored research applications.
With a commitment to excellence in developing high-quality biological tools, our company stands at the forefront of the research landscape, offering KLRK1 Gene Knockout Cell Lines as an essential resource for pioneering studies in immune and cancer biology.
Please note that all services are for research use only. Not intended for any clinical use.
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