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KIF21B Knockout Cell Lines

Gene: KIF21B

Official Full Name: kinesin family member 21Bprovided by HGNC

Gene Summary: This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29961 KIF21B Knockout cell line (HCT 116) Human KIF21B 1:2~1:4 Negative Online Inquiry
KO29962 KIF21B Knockout cell line (A549) Human KIF21B 1:3~1:4 Negative Online Inquiry

Background

KIF21B Gene Knockout Cell Lines represent a crucial advancement in genetic research and experimental biology. These cell lines have been engineered to lack the KIF21B gene, which encodes a kinesin motor protein that is integral to various cellular processes, including axonal transport and cell division. The absence of KIF21B allows researchers to dissect its role in these biological pathways, providing valuable insight into its functional implications in health and disease.

The key mechanism of these knockout cell lines lies in targeted gene editing methodologies, such as CRISPR/Cas9 technology, which enables precise alterations in the genome. By observing the cellular behavior and pathways in the absence of KIF21B, scientists can better understand the protein's contributions to critical processes like neurodevelopment and intracellular trafficking. This capability makes the KIF21B Gene Knockout Cell Lines an invaluable tool for examining the biochemical and molecular underpinnings of various pathologies, including neurodegenerative disorders and cancer.

The scientific significance of these cell lines extends into both research and clinical arenas. They serve as a platform for drug discovery and toxicity studies, enabling the testing of new therapeutic strategies aimed at restoring or compensating for the loss of KIF21B function. Moreover, these knockout lines enhance the capacity for functional genomics studies aimed at identifying therapeutic targets and biomarkers.

Unique to our offering, these cell lines are characterized by a high knockout efficiency and stability, allowing for reproducible experimental results. Unlike traditional models, KIF21B Gene Knockout Cell Lines provide clear, specific insights into gene function without confounding variables, supporting more robust scientific inquiries.

For researchers and clinicians looking to push the limits of current biological understanding, the KIF21B Gene Knockout Cell Lines represent not just an innovative tool but a pathway to new discoveries. Our company is committed to delivering cutting-edge biological products backed by rigorous scientific validation, ensuring that you have access to the highest quality tools for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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