Gene: ILRUN
Official Full Name: inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by HGNC
Gene Summary: This gene encodes a protein with N-terminal ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene 1 (NBR1)-like domains. The protein acts an inhibitor of antiviral and proinflammatory cytokine transcription and as a regulator of the renin-angiotensin-aldosterone system (RAAS). [provided by RefSeq, Jul 2021]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16951 | ILRUN Knockout cell line (HeLa) | Human | ILRUN | 1:3~1:6 | Negative | Online Inquiry |
KO16952 | ILRUN Knockout cell line (HCT 116) | Human | ILRUN | 1:2~1:4 | Negative | Online Inquiry |
KO16953 | ILRUN Knockout cell line (HEK293) | Human | ILRUN | 1:3~1:6 | Negative | Online Inquiry |
KO16954 | ILRUN Knockout cell line (A549) | Human | ILRUN | 1:3~1:4 | Negative | Online Inquiry |
ILRUN Gene Knockout Cell Lines are state-of-the-art tools designed for the precise manipulation of gene expression in mammalian cells. Utilizing advanced CRISPR-Cas9 technology, these cell lines enable researchers to efficiently create knockout models, allowing for the functional study of gene loss in cellular processes. Each cell line within the ILRUN product range is meticulously developed, ensuring that specific genes of interest are selectively disrupted, which facilitates investigations into gene function, signaling pathways, and disease mechanisms.
The primary mechanism of action involves the introduction of double-strand breaks in targeted genomic regions, which the cell attempts to repair using non-homologous end joining, often resulting in insertions or deletions (indels) that disrupt the reading frame of the gene. This allows for a thorough examination of the resultant phenotypic changes, driving insights in fields such as cancer research, drug development, and genetic disorders.
The scientific importance of ILRUN Gene Knockout Cell Lines lies in their ability to provide robust models for hypothesis-driven research. They are invaluable in both academic and clinical settings, enabling studies that can lead to new therapeutic strategies and enhance understanding of complex biological systems. Compared to conventional knockdown methods involving siRNA or shRNA, CRISPR-based knockout models offer lasting genetic modifications that lead to stable cell lines ideal for longitudinal studies.
Unique selling points of ILRUN Gene Knockout Cell Lines include their high efficiency and specificity, as well as the comprehensive support provided for experimental design and implementation. These features significantly reduce time and resource expenditure, allowing researchers to focus on their investigations rather than troubleshooting model creation.
For researchers, clinicians, and other target users, ILRUN Gene Knockout Cell Lines represent an essential resource, simplifying the pathway to significant discoveries in biological research and therapeutic development. As a leader in biotechnological innovation, our company prides itself on harnessing cutting-edge techniques and offering superior products that empower the scientific community. Our expertise ensures that customers receive high-quality, reliable tools tailored to advance their research initiatives.
Please note that all services are for research use only. Not intended for any clinical use.
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