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IKZF2 Knockout Cell Lines

Gene: IKZF2

Official Full Name: IKAROS family zinc finger 2provided by HGNC

Gene Summary: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30322 IKZF2 Knockout cell line (HeLa) Human IKZF2 1:3~1:6 Negative Online Inquiry
KO30323 IKZF2 Knockout cell line (HEK293) Human IKZF2 1:3~1:6 Negative Online Inquiry

Background

IKZF2 Gene Knockout Cell Lines are advanced biological tools designed for the study of the IKZF2 gene, which encodes for the Ikaros family zinc finger 2 protein involved in lymphoid development and immune regulation. These cell lines are engineered to specifically disrupt the IKZF2 gene, creating a valuable resource for researchers investigating its role in various biological processes and diseases, particularly in immunology and oncology.

The primary mechanism of the IKZF2 Gene Knockout Cell Lines involves CRISPR-Cas9 technology, which allows for precise gene editing. This method facilitates the generation of knockout cell lines that lack functional IKZF2, enabling the exploration of the gene's contributions to cell proliferation, differentiation, and apoptosis. By studying these knockout lines, scientists can dissect the pathways influenced by IKZF2 and gain insights into its implications in T-cell-mediated immune responses and pathological conditions like leukemia and lymphoma.

The scientific importance of these knockout lines is underscored by their applications in both research and clinical settings. They serve as crucial models for the investigation of immune dysregulation and can potentially guide the development of novel therapeutic strategies targeting diseases linked to the IKZF2 pathway. Furthermore, the use of these cell lines can aid in drug screening and efficacy testing, allowing for the identification of compounds that may restore normal functionality in IKZF2-deficient cells.

What sets IKZF2 Gene Knockout Cell Lines apart from alternatives on the market is their high specificity and reliability, along with comprehensive documentation detailing their generation, characterization, and application. Researchers can trust that these knockouts provide a robust foundation for their studies, facilitated by a background free from unwanted off-target effects.

This product is invaluable to researchers and clinicians alike, as it not only furthers our understanding of critical immune pathways but also supports the ongoing quest for innovative treatments in immune-related disorders and malignancies.

Our company specializes in producing high-quality biological products with a focus on precision and utility. With extensive experience in genetic engineering and cell line development, we are dedicated to providing researchers with the tools they need to advance their work toward groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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