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IER3 Knockout Cell Lines

Gene: IER3

Official Full Name: immediate early response 3provided by HGNC

Gene Summary: This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33774 IER3 Knockout cell line (HeLa) Human IER3 1:3~1:6 Negative Online Inquiry
KO33775 IER3 Knockout cell line (HCT 116) Human IER3 1:2~1:4 Negative Online Inquiry
KO33776 IER3 Knockout cell line (HEK293) Human IER3 1:3~1:6 Negative Online Inquiry
KO33777 IER3 Knockout cell line (A549) Human IER3 1:3~1:4 Negative Online Inquiry

Background

IER3 Gene Knockout Cell Lines are genetically modified cell lines designed to study the function of the IER3 gene, known for its role in regulating cell growth, apoptosis, and response to stress stimuli. The targeted knockout of the IER3 gene allows researchers to investigate its contributions to various cellular processes and disease states, thereby offering significant insights into cancer biology, immunology, and therapeutic resistance.

These cell lines employ advanced CRISPR-Cas9 technology to achieve precise gene editing, effectively eliminating the expression of IER3 while maintaining the integrity of the host cell line’s genomic context. As a result, researchers can observe phenotypic changes and biochemical pathways that are influenced by the loss of IER3, making these cell lines invaluable tools for exploring the gene's role in cell signaling and therapeutic responses.

The scientific importance of IER3 knockout cell lines spans across various research domains, including oncology, where understanding of tumor progression and invasion can be deepened. Additionally, in immunotherapy research, these models can elucidate mechanisms behind immune evasion strategies employed by tumors, paving the way for improved treatment protocols. Their applications can further extend to drug discovery efforts aimed at targeting malignancies with aberrant IER3 expression.

In comparison to traditional tools, such as RNA interference or pharmacological inhibitors, IER3 Gene Knockout Cell Lines provide a stable and permanent genetic alteration, allowing for reproducible results and long-term studies without the confounding effects of transient suppression. Such permanence enhances the reliability of experimental findings and enables comprehensive validation of observed effects.

For researchers and clinicians alike, these cell lines not only facilitate a deeper understanding of crucial molecular mechanisms but also serve as platforms for the development of novel therapeutic strategies. Our company has a longstanding commitment to advancing scientific research through high-quality biological products, and with our specialized expertise in gene editing technologies, we ensure that our IER3 Gene Knockout Cell Lines are of the highest standard, tailored to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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