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ICE2 Knockout Cell Lines

Gene: ICE2

Official Full Name: interactor of little elongation complex ELL subunit 2provided by HGNC

Gene Summary: This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17030 ICE2 Knockout cell line (HeLa) Human ICE2 1:3~1:6 Negative Online Inquiry
KO17031 ICE2 Knockout cell line (HCT 116) Human ICE2 1:2~1:4 Negative Online Inquiry
KO17032 ICE2 Knockout cell line (HEK293) Human ICE2 1:3~1:6 Negative Online Inquiry

Background

ICE2 Gene Knockout Cell Lines are engineered cellular models derived from host organisms that have undergone targeted gene editing to disrupt the ICE2 gene. This precise modification is typically achieved through CRISPR-Cas9 technology or other advanced gene-editing techniques, which allows researchers to investigate gene function, signaling pathways, and the role of ICE2 in various biological processes. By eliminating the expression of ICE2, these cell lines serve as invaluable tools for studying the consequences of its absence on cellular physiology.

The primary function of ICE2 Gene Knockout Cell Lines involves their application in understanding gene interaction networks and functional genomics. Researchers can utilize these cell lines to elucidate the phenotypic changes resulting from ICE2 disruption, providing insights into related pathways and potential therapeutic targets for diseases where ICE2 plays a pivotal role, such as certain cancers or metabolic disorders. These knockout models are crucial for validating gene function through loss-of-function studies, thereby contributing to knowledge advancement in molecular biology and genetics.

From a scientific perspective, ICE2 Gene Knockout Cell Lines are indispensable in both academic research and clinical settings. They facilitate the identification of gene interactions and the impact of genetic anomalies on cellular behavior, greatly enhancing the feasibility of drug discovery and the development of innovative therapies. Compared to traditional cell lines or less precise knockout models, ICE2 Gene Knockout Cell Lines offer superior specificity and reliability, ensuring reproducible results that are crucial for scientific rigor.

The unique advantages of these cell lines lie in their robustness and the depth of insights they can provide. Researchers and clinicians seeking to explore the implications of the ICE2 gene in various contexts will find these knockout lines exceptionally conducive to their work. Moreover, for drug developers looking to pinpoint new targets for intervention or test compound efficacy, these models represent an essential step forward.

Our company is dedicated to providing high-quality biological products that empower research and enhance scientific understanding. With expertise in cellular models and cutting-edge gene editing technologies, we offer ICE2 Gene Knockout Cell Lines as part of our comprehensive portfolio, designed to support the evolving needs of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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