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HOXA4 Knockout Cell Lines

Gene: HOXA4

Official Full Name: homeobox A4provided by HGNC

Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37301 HOXA4 Knockout cell line (HeLa) Human HOXA4 1:3~1:6 Negative Online Inquiry
KO37302 HOXA4 Knockout cell line (HCT 116) Human HOXA4 1:2~1:4 Negative Online Inquiry
KO37303 HOXA4 Knockout cell line (HEK293) Human HOXA4 1:3~1:6 Negative Online Inquiry
KO37304 HOXA4 Knockout cell line (A549) Human HOXA4 1:3~1:4 Negative Online Inquiry

Background

HOXA4 Gene Knockout Cell Lines are specially engineered cellular models that have undergone targeted gene editing to disable the HOXA4 gene, a member of the Homeobox gene family critical for embryonic development and cell differentiation. By employing advanced CRISPR-Cas9 technology, these cell lines enable precise elimination of HOXA4 function, allowing researchers to investigate the gene's role in various biological processes and its involvement in diseases.

The primary function of HOXA4 gene knockout is to facilitate the exploration of HOXA4's regulatory mechanisms, particularly its influence on gene expression, cellular morphology, and developmental pathways. Understanding how the absence of HOXA4 affects cellular behavior is crucial for elucidating potential dysregulations that lead to developmental disorders or cancers, making these cell lines invaluable for conducting mechanistic studies.

In scientific research, particularly in developmental biology and oncology, HOXA4 is recognized for its role in the regulation of stem cell pluripotency and differentiation. By utilizing these knockout cell lines, researchers can accurately model and study the implications of HOXA4 deregulation, offering insights that can translate into therapeutic strategies. In clinical settings, such models can enhance drug development processes and pave the way for personalized medicine approaches.

Compared to conventional cell lines, which express HOXA4, our HOXA4 Gene Knockout Cell Lines provide a unique advantage by offering a controlled environment to examine specific gene functions without confounding effects. As a result, they allow for clearer interpretation of experimental outcomes, ultimately leading to more robust scientific findings.

Valuable to both researchers and clinicians, these knockout cell lines empower studies that seek to parse the complexities of gene networks and their roles in disease. By integrating HOXA4 as a focal point, users can advance their research agendas and contribute to innovation in therapeutic interventions.

Our company specializes in the development of high-quality, precisely engineered biological products, geared towards facilitating groundbreaking research in genomics and molecular biology. With an emphasis on cutting-edge technology and scientific rigor, we are committed to providing researchers with the tools necessary to unlock new avenues of understanding in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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