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HDAC11 Knockout Cell Lines

Gene: HDAC11

Official Full Name: histone deacetylase 11provided by HGNC

Gene Summary: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17154 HDAC11 Knockout cell line (HeLa) Human HDAC11 1:3~1:6 Negative Online Inquiry
KO17155 HDAC11 Knockout cell line (HCT 116) Human HDAC11 1:2~1:4 Negative Online Inquiry
KO17156 HDAC11 Knockout cell line (HEK293) Human HDAC11 1:3~1:6 Negative Online Inquiry
KO17157 HDAC11 Knockout cell line (A549) Human HDAC11 1:3~1:4 Negative Online Inquiry

Background

HDAC11 Gene Knockout Cell Lines are meticulously engineered cellular models where the HDAC11 gene has been specifically disrupted or knocked out, allowing for detailed exploration of the biological pathways regulated by this key histone deacetylase. The function of HDAC11 is integral to various cellular processes, including the regulation of gene expression, differentiation, and cell cycle progression. By utilizing these knockout cell lines, researchers can investigate the consequential cellular dynamics that arise from the absence of HDAC11 activity.

The mechanism of action for these cell lines is rooted in the targeted CRISPR-Cas9 gene-editing technology, which precisely excises the HDAC11 gene, leading to a loss of function and revealing the gene's role in epigenetic modulation. This allows scientists to examine how changes in histone acetylation status influence chromatin structure and gene transcription, facilitating deeper insights into tumor biology, immune responses, and neurodegenerative diseases.

The scientific importance of HDAC11 Gene Knockout Cell Lines cannot be overstated; they serve as invaluable tools for advancing our understanding of complex diseases and therapeutic interventions. These cell lines have applications in both research and clinical settings, particularly in developing HDAC inhibitors as potential cancer treatments and evaluating their effects on various biological systems.

What sets these cell lines apart from alternatives is their high specificity and validated knockout efficiency, ensuring robust and reproducible results. Additionally, they come with comprehensive support, including validation data and protocols to aid users in experimental design and implementation.

By integrating HDAC11 Gene Knockout Cell Lines into their research arsenal, scientists and clinicians can uncover new therapeutic targets and advance precision medicine. Our company is dedicated to providing top-tier biological products backed by extensive scientific expertise, ensuring that you have access to the highest quality tools for your research and clinical needs.

Please note that all services are for research use only. Not intended for any clinical use.

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