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HAL Knockout Cell Lines

Gene: HAL

Official Full Name: histidine ammonia-lyaseprovided by HGNC

Gene Summary: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37419 HAL Knockout cell line (HCT 116) Human HAL 1:2~1:4 Negative Online Inquiry

Background

HAL Gene Knockout Cell Lines are specialized biological resources engineered to facilitate the study of gene function and regulation in vitro. These cell lines have been meticulously developed using advanced CRISPR-Cas9 genome-editing technology to introduce targeted mutations that disrupt the expression of the HAL gene, which is known to play a critical role in various metabolic pathways and disease processes. By eliminating the HAL gene, researchers can investigate its biological implications, enabling insights into metabolic disorders, cancer biology, and therapeutic innovations.

The primary function of HAL Gene Knockout Cell Lines is to serve as a platform for exploring the pathways in which the HAL gene is implicated. By employing these cell lines, scientists can analyze alterations in cellular behavior, gene expression profiles, and biochemical assays in a controlled environment. This mechanistic understanding is essential for deciphering the gene's role in health and disease, aiding in the development of targeted therapies and predictive models.

In both research and clinical settings, HAL Gene Knockout Cell Lines hold significant scientific importance. They can be utilized in drug discovery processes, toxicity evaluations, and pathway analysis, allowing for a deeper understanding of gene interactions and cellular responses. Moreover, these cell lines possess the potential to streamline the development of personalized medicine by tailoring therapeutic strategies based on specific genetic profiles.

One of the key advantages of HAL Gene Knockout Cell Lines is their high specificity and reproducibility compared to older techniques like RNA interference or nonspecific gene silencing methods. The precise targeting provided by CRISPR technology results in complete knockout of the HAL gene, affording more definitive results and minimizing off-target effects that could confound experimental outcomes. This translates to enhanced reliability in data interpretation, which is critical when making scientifically grounded conclusions.

Researchers and clinicians using HAL Gene Knockout Cell Lines will find great value in their capabilities to illuminate complex biological questions and facilitate novel therapeutic discoveries. As a leading provider of cutting-edge biological products, our company is committed to equipping the scientific community with high-quality, rigorously validated tools like the HAL Gene Knockout Cell Lines, empowering breakthroughs in life sciences and clinical research.

Please note that all services are for research use only. Not intended for any clinical use.

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