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GPR155 Knockout Cell Lines

Gene: GPR155

Official Full Name: G protein-coupled receptor 155provided by HGNC

Gene Summary: Enables cholesterol binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and positive regulation of TORC1 signaling. Located in extracellular exosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00419 GPR155 Knockout cell line (HEK293) Human GPR155 1:3~1:6 Negative Online Inquiry
KO21947 GPR155 Knockout cell line (HeLa) Human GPR155 1:3~1:6 Negative Online Inquiry
KO21948 GPR155 Knockout cell line (HCT 116) Human GPR155 1:2~1:4 Negative Online Inquiry
KO21949 GPR155 Knockout cell line (A549) Human GPR155 1:3~1:4 Negative Online Inquiry

Background

GPR155 Gene Knockout Cell Lines are advanced cellular models specifically engineered to silence the GPR155 gene, which encodes a G protein-coupled receptor implicated in various physiological processes, including neurodevelopment and synaptic activity. These cell lines are generated using CRISPR/Cas9 technology, ensuring high efficiency and precision in gene disruption. As a result, researchers can investigate the specific functions of GPR155, elucidating its role in neuronal signaling pathways and its potential impact on disorders such as anxiety, depression, and schizophrenia.

The primary function of GPR155 Gene Knockout Cell Lines is to serve as a valuable tool for studying the consequences of GPR155 gene loss on cellular behaviors, signaling cascades, and overall cellular functions. These models provide insights into how GPR155 regulates neurotransmitter release and neuronal excitability, facilitating a deeper understanding of its contribution to neuropsychiatric conditions. The ability to observe phenotypic changes in these knockout lines allows researchers to identify therapeutic targets and biomarkers for drug development.

From a scientific standpoint, these cell lines are significant in both research and clinical applications. They offer a streamlined system for screening potential compounds that could modulate GPR155-related pathways, ultimately aiding in the development of novel pharmacological interventions. Furthermore, their robustness and reproducibility set a benchmark for studies focusing on GPCRs and neurobiology.

In comparison to alternative models, such as wild-type cell lines or other gene-editing systems, GPR155 Gene Knockout Cell Lines provide distinct advantages, including greater specificity in gene targeting and the ability to study gene function in the native cellular environment. This allows for more reliable data, which is critical for the transition from basic research to clinical applications.

For researchers and clinicians dedicated to unraveling the complexities of neurobiology and developing new therapeutic strategies, GPR155 Gene Knockout Cell Lines are indispensable. They bridge the gap between genetic investigation and practical treatment pathways, showcasing the innovative potential of genetic models. Our company, with years of expertise in genetic engineering and cell line development, is committed to providing high-quality biological products that empower research in the life sciences and contribute to advancements in health care.

Please note that all services are for research use only. Not intended for any clinical use.

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