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FN1 Knockout Cell Lines

Gene: FN1

Official Full Name: fibronectin 1provided by HGNC

Gene Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01323 FN1 Knockout cell line (Hep G2) Human FN1 1:2~1:4 Negative Online Inquiry
KO10361 FN1 Knockout cell line (HeLa) Human FN1 1:3~1:6 Negative Online Inquiry
KO10362 FN1 Knockout cell line (HCT 116) Human FN1 1:2~1:4 Negative Online Inquiry
KO10363 FN1 Knockout cell line (HEK293) Human FN1 1:3~1:6 Negative Online Inquiry
KO10364 FN1 Knockout cell line (A549) Human FN1 1:3~1:4 Negative Online Inquiry

Background

FN1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the fibroectin 1 (FN1) gene, which encodes the extracellular matrix glycoprotein fibronectin. These cell lines serve as vital tools for investigating the role of fibronectin in cellular processes such as adhesion, migration, and differentiation. By omitting FN1, researchers can elucidate the molecular pathways influenced by fibronectin, enhancing our understanding of tissue development, regenerative medicine, and various pathological conditions, including cancer metastasis and fibrotic diseases.

The mechanisms underlying the utility of FN1 Gene Knockout Cell Lines reside in their ability to mimic disease states where fibronectin expression is altered or absent. This allows for in-depth analysis of how the absence of this key matrix component affects cellular behavior and signaling cascades. In clinical and research settings, these cell lines can be utilized for drug screening, providing insights into therapeutic agents that could target fibronectin-related pathways. Furthermore, they are instrumental in studying stem cell biology and the mechanisms of wound healing, making them valuable for regenerative therapy applications.

One significant advantage of FN1 Gene Knockout Cell Lines is their specificity and reliability, providing a controlled environment that requires less variability than primary cell cultures. Compared to alternative models, these knockout lines offer enhanced reproducibility and enable focused studies on FN1's role without confounding influences from other matrix components.

For researchers and clinicians aiming to expand their knowledge in cellular biology, these knockout cell lines present indispensable resources for exploring the complexities of cell-matrix interactions and developing new therapeutic strategies. Our company specializes in providing high-quality biological products, and our FN1 Gene Knockout Cell Lines exemplify our commitment to facilitating groundbreaking research and enabling scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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