Home / FGL1 Knockout Cell Lines

FGL1 Knockout Cell Lines

Gene: FGL1

Official Full Name: fibrinogen like 1provided by HGNC

Gene Summary: Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37889 FGL1 Knockout cell line (A549) Human FGL1 1:3~1:4 Negative Online Inquiry

Background

FGL1 Gene Knockout Cell Lines are genetically engineered cellular models that have had the FGL1 gene selectively disrupted. This targeted approach utilizes CRISPR/Cas9 technology to induce site-specific mutations within the FGL1 gene, leading to a loss of function. The resultant cell lines serve as vital tools for scientists investigating the role of FGL1 in various biological processes, including immunity, cell signaling, and tumor growth.

The primary function of FGL1 involves its regulatory capacity in the immune system, acting as an immune checkpoint molecule that can modulate T-cell responses. By providing a platform to study the effect of FGL1 knockout, researchers can elucidate its involvement in pathological conditions, such as cancer and chronic infections, facilitating the identification of novel therapeutic targets. The knockout cell lines enable deeper insights into cellular interactions and the molecular mechanisms by which FGL1 influences immune regulation, thereby augmenting our understanding of immune evasion in tumors.

The scientific importance of FGL1 Gene Knockout Cell Lines extends to their application in preclinical research, including drug discovery and validation studies. They are particularly valuable in assessing the efficacy of immune-oncology therapies and in exploring cellular responses to various treatments, bridging a crucial gap in translational research.

Compared to alternative products, these knockout cell lines provide an unparalleled specificity and reproducibility, coupled with a user-friendly approach for researchers. They bypass the variability associated with other methods such as knockdown techniques, ensuring consistent experimental outcomes.

For researchers and clinicians striving to enhance therapeutic strategies or delve into the complexities of immune mechanisms, FGL1 Gene Knockout Cell Lines offer a transformative solution. Their characterization allows for significant advancements in both academic and clinical domains, making them an essential addition to any laboratory focused on cutting-edge biological research.

With a strong commitment to innovation, our company specializes in offering high-quality, genetically modified cell lines that empower breakthroughs in biological research, supporting the scientific community in its quest for discovery and therapeutic advancement.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.