Gene: FBXW7
Official Full Name: F-box and WD repeat domain containing 7provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00241 | FBXW7 gRNA1-gRNA2 KO plasmid | FBXW7 | $850 | |||
GP00259 | FBXW7 gRNA3-gRNA4 KO plasmid | FBXW7 | $850 | |||
GP00413 | FBXW7 gRNA1-gRNA2 KO plasmid | FBXW7 | $850 | |||
KO00218 | FBXW7 Knockout cell line (HEK293) | Human | FBXW7 | 1:3~1:6 | Negative | Online Inquiry |
KO00383 | FBXW7 Knockout cell line(5637) | Human | FBXW7 | 1:2-1:3 | Negative | Online Inquiry |
KO00578 | FBXW7 Knockout cell line(SW480) | Human | FBXW7 | 1:2~1:4 | Negative | Online Inquiry |
KO00937 | FBXW7 Knockout cell line(HCT 116) | Human | FBXW7 | 1:2~1:4 | Negative | Online Inquiry |
KO17648 | FBXW7 Knockout cell line (HeLa) | Human | FBXW7 | 1:3~1:6 | Negative | Online Inquiry |
KO17649 | FBXW7 Knockout cell line (A549) | Human | FBXW7 | 1:3~1:4 | Negative | Online Inquiry |
FBXW7 Gene Knockout Cell Lines consist of genetically modified cells that have had the FBXW7 gene specifically disrupted or deleted. FBXW7, known as F-box and WD-40 domain protein 7, plays a critical role in the ubiquitin-proteasome system, which is essential for the regulation of protein degradation and cellular homeostasis. This product enables researchers to investigate the biological implications of FBXW7 loss, thereby gaining insights into its contributions to processes such as cell cycle regulation, signal transduction, and tumorigenesis.
DBecause these knockout cell lines are devoid of FBXW7 expression, they ideally model conditions associated with various cancers and metabolic disorders, thus serving as invaluable tools for studying the underlying mechanisms of disease. Moreover, the knockout cells can be employed to screen for potential therapeutic targets, enhancing drug discovery and development efforts. Additionally, these cell lines are instrumental in elucidating how the disruption of the FBXW7 pathway affects cellular behaviors such as proliferation, differentiation, and apoptosis, making them suitable for both research applications and preclinical studies.
One distinct advantage of using our FBXW7 Gene Knockout Cell Lines is their high specificity and reproducibility, ensuring that researchers achieve consistent and reliable results. Compared to other knockout models, which may rely on transient transfection or non-specific genome editing methods, our cell lines provide a stable and controlled environment for long-term studies. This reliability reduces experimental variability, allowing for a more precise analysis of FBXW7-related pathways.
In summary, the FBXW7 Gene Knockout Cell Lines represent a powerful asset for researchers and clinicians focused on cancer biology and metabolic disorders. By providing customizable, high-quality, and stable cell lines, we empower scientists to enhance their understanding of critical biological pathways and ultimately drive innovative therapeutic strategies. Our company prides itself on a commitment to excellence in genetic engineering, providing cutting-edge biological products that facilitate groundbreaking research and support advancements in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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