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FBXO31 Knockout Cell Lines

Gene: FBXO31

Official Full Name: F-box protein 31provided by HGNC

Gene Summary: This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30789 FBXO31 Knockout cell line (HeLa) Human FBXO31 1:3~1:6 Negative Online Inquiry
KO30790 FBXO31 Knockout cell line (HCT 116) Human FBXO31 1:2~1:4 Negative Online Inquiry
KO30791 FBXO31 Knockout cell line (HEK293) Human FBXO31 1:3~1:6 Negative Online Inquiry
KO30792 FBXO31 Knockout cell line (A549) Human FBXO31 1:3~1:4 Negative Online Inquiry

Background

FBXO31 Gene Knockout Cell Lines represent pioneering biotechnological tools designed for functional genomics research. These cell lines have been genetically engineered to disable the FBXO31 gene, which encodes a protein integral to various cellular processes, including cell cycle regulation and targeted protein degradation through the ubiquitin-proteasome pathway. By knocking out FBXO31, researchers can closely examine the role this gene plays in critical biological functions, including apoptosis, tumorigenesis, and cell proliferation.

The mechanism of action lies in the disruption of the FBXO31 protein’s ability to interact with its substrates, ultimately leading to altered signaling pathways that govern cell behavior. This makes the knockout cell lines invaluable for elucidating the functional consequences of FBXO31 loss and its contributions to various pathological states, especially in cancer research. By leveraging these models, scientists can unlock insights into tumor biology, paving the way for potential therapeutic targets.

FBXO31 Gene Knockout Cell Lines are exceptionally beneficial in both research and clinical applications, allowing for robust functional assays, drug screening, and validation of therapeutic strategies. Unlike conventional methods that rely on RNA interference, these knockout models provide stable and consistent gene disruption, facilitating reproducibility in experimental outcomes.

For researchers and clinicians, the ability to study the consequences of FBXO31 loss in a controlled environment significantly enhances the potential for groundbreaking discoveries. The unique selling point of our cell lines is the reliability and precision they offer, driven by cutting-edge gene-editing technologies such as CRISPR-Cas9, ensuring a user-friendly experience that reduces experimental variability.

Our company is dedicated to advancing the frontiers of life sciences by providing high-quality biological products that meet the rigorous standards of academic and clinical research. With our expertise in creating genetically modified cell lines, we continue to empower scientists to innovate and explore new dimensions in genomic research.

Please note that all services are for research use only. Not intended for any clinical use.

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