Gene: DUX3
Official Full Name: double homeobox 3provided by HGNC
Gene Summary: The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX3, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28029 | DUX3 Knockout cell line (HeLa) | Human | DUX3 | 1:3~1:6 | Negative | Online Inquiry |
KO28030 | DUX3 Knockout cell line (HCT 116) | Human | DUX3 | 1:2~1:4 | Negative | Online Inquiry |
KO28031 | DUX3 Knockout cell line (HEK293) | Human | DUX3 | 1:3~1:6 | Negative | Online Inquiry |
KO28032 | DUX3 Knockout cell line (A549) | Human | DUX3 | 1:3~1:4 | Negative | Online Inquiry |
DUX3 Gene Knockout Cell Lines are a specialized set of engineered cells designed to elucidate the functions of the DUX3 gene, which plays a critical role in muscle differentiation and embryonic development. These cell lines have been meticulously created using CRISPR/Cas9 gene-editing technology to specifically disrupt the DUX3 gene, allowing researchers to study the gene's absence and its downstream effects on cellular behavior.
The key mechanism of action involves the targeted deletion of the DUX3 gene, resulting in alterations in gene expression profiles and cellular pathways that are crucial for muscle and possibly neuronal development. By utilizing these knockout cell lines, researchers can perform functional assays that reveal insights into the role of DUX3 in myogenesis, highlighting its importance in both normal physiology and disease states, including certain muscular dystrophies.
Scientifically, DUX3 Gene Knockout Cell Lines hold significant promise in various research arenas such as developmental biology, muscle regeneration, and gene therapy. They can be pivotal in preclinical studies aimed at evaluating therapeutic strategies for genetic diseases linked to DUX3 dysfunction. Furthermore, these cell lines provide an invaluable platform for drug screening, as they enable the assessment of compound effects on muscle regeneration and differentiation processes.
What sets DUX3 Gene Knockout Cell Lines apart from alternatives is their specificity and reliability. Engineered with precision and validated for consistent genetic knockout, these cell lines minimize variability, ensuring that researchers can draw accurate and reproducible conclusions. The availability of these specialized cell lines eliminates the need for cumbersome and time-consuming processes typically associated with traditional gene knockout methods.
For researchers and clinicians seeking to push the boundaries of our understanding of muscle biology and potential therapeutic avenues, DUX3 Gene Knockout Cell Lines represent a significant advancement in biological research tools. By choosing our product, users are not only investing in cutting-edge technology but also partnering with a company that is committed to excellence in the field of genetic research and cellular biology. Our expertise guarantees high-quality products backed by rigorous validation, ensuring your research translates into meaningful scientific discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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