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DUS4L Knockout Cell Lines

Gene: DUS4L

Official Full Name: dihydrouridine synthase 4 likeprovided by HGNC

Gene Summary: Predicted to enable tRNA dihydrouridine synthase activity. Involved in tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00441 DUS4L gRNA1-gRNA2 KO plasmid DUS4L $850
GP00442 DUS4L gRNA1-gRNA2 KO plasmid DUS4L $850
KO00710 DUS4L Knockout cell line(U-87 MG) Human DUS4L 1:3~1:4 Negative Online Inquiry
KO00728 DUS4L Knockout cell line (Hep G2) Human DUS4L 1:2~1:4 Negative Online Inquiry

Background

DUS4L Gene Knockout Cell Lines are a sophisticated tool designed for the functional analysis of the DUS4L gene, which has been implicated in various cellular processes, including RNA metabolism and cell proliferation. These cell lines are engineered using advanced CRISPR/Cas9 technology to achieve precise gene disruption, allowing researchers to investigate the phenotypic consequences of DUS4L loss. By comparing knockout cells with wild-type counterparts, scientists can elucidate the gene's role in vital biological pathways, enhancing our understanding of its contributions to cellular function.

The key mechanism behind DUS4L Gene Knockout Cell Lines is the specificity and efficiency of the CRISPR/Cas9 system, which introduces double-strand breaks in the genome at targeted sites, leading to the error-prone repair through non-homologous end joining. This results in frameshift mutations that effectively disable gene expression. The resulting cell lines facilitate a wide range of experimental studies, from assessing cellular responses under pathological conditions to testing potential therapeutic interventions.

The scientific importance of DUS4L Gene Knockout Cell Lines lies in their versatility for both basic and applied research, particularly in fields such as cancer biology and regenerative medicine. By providing a model system that simulates gene loss, researchers can better understand diseases where DUS4L may play a role. Moreover, these cell lines pave the way for developing novel therapeutic strategies targeting RNA-related pathways.

What sets DUS4L Gene Knockout Cell Lines apart from alternative models is their rigorously validated genetic modification, which ensures reliable and reproducible experimental outcomes. Each line has been thoroughly characterized to confirm complete knockout of the target gene, providing researchers with the confidence needed for impactful studies. Additionally, they are compatible with various assay formats, from gene expression analysis to high-throughput screening.

For researchers and clinicians seeking to unravel the complexities of gene function, DUS4L Gene Knockout Cell Lines represent an indispensable asset. Their reliable performance and robust genetic characterization make them a superior choice for addressing pressing biological questions. As a leader in the biological products sector, our company is committed to providing cutting-edge research tools backed by extensive expertise and rigorous quality control to support your endeavors in advancing scientific knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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