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DMXL2 Knockout Cell Lines

Gene: DMXL2

Official Full Name: Dmx like 2provided by HGNC

Gene Summary: This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29488 DMXL2 Knockout cell line (HeLa) Human DMXL2 1:3~1:6 Negative Online Inquiry
KO29489 DMXL2 Knockout cell line (HCT 116) Human DMXL2 1:2~1:4 Negative Online Inquiry
KO29490 DMXL2 Knockout cell line (HEK293) Human DMXL2 1:3~1:6 Negative Online Inquiry
KO29491 DMXL2 Knockout cell line (A549) Human DMXL2 1:3~1:4 Negative Online Inquiry

Background

DMXL2 Gene Knockout Cell Lines are specifically engineered human cell lines in which the DMXL2 gene has been completely inactivated through advanced CRISPR-Cas9 gene editing technology. The DMXL2 gene, recognized for its roles in cellular signaling and transcriptional regulation, is pivotal in various biological pathways relevant to cancer progression and neurodevelopmental disorders. These knockout cell lines serve as critical tools for understanding the functional implications of DMXL2 loss, allowing researchers to investigate altered cellular behaviors and signaling cascades.

The key mechanism through which these cell lines operate centers on the absence of DMXL2, leading to alterations in gene expression profiles and cellular responses. By utilizing these knockout models, researchers can dissect the contributions of DMXL2 to metabolic processes, cell cycle regulation, and other vital cellular functions, thereby illuminating potential therapeutic targets.

Scientific applications of DMXL2 Gene Knockout Cell Lines are manifold, spanning both in vitro and in vivo research settings. In research, these lines facilitate studies on gene function, elucidating pathways that may play a role in diseases such as cancers and neurological disorders. Clinically, insights gained from these models can guide the development of targeted interventions, helping to translate bench research into clinical applications.

Compared to traditional methods of gene inactivation, such as RNA interference or chemical inhibitors, DMXL2 Gene Knockout Cell Lines provide a more robust and permanent solution to study the effects of gene loss. This stability ensures that experimental results are reproducible, making these cell lines valuable in the rigorous landscapes of both academic and pharmaceutical research.

The value of DMXL2 Gene Knockout Cell Lines lies in their ability to provide substantive insights into complex biological systems and disease mechanisms, empowering researchers and clinicians alike to drive innovations in therapeutic strategies. Our company excels in the development of high-quality cellular models and offers comprehensive support, ensuring that our clients can effectively leverage this cutting-edge product to advance their research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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