Gene: DEF6
Official Full Name: DEF6 guanine nucleotide exchange factorprovided by HGNC
Gene Summary: DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23366 | DEF6 Knockout cell line (HCT 116) | Human | DEF6 | 1:2~1:4 | Negative | Online Inquiry |
KO23367 | DEF6 Knockout cell line (HEK293) | Human | DEF6 | 1:3~1:6 | Negative | Online Inquiry |
DEF6 Gene Knockout Cell Lines are precision-engineered cellular models designed for research involving the DEF6 gene, which is integral to various cellular processes, including immune response regulation and signal transduction pathways. By employing CRISPR-Cas9 technology, these cell lines have been crafted to eliminate the expression of the DEF6 gene, enabling scientists to investigate its function in detail and discern the molecular mechanisms that underpin its role in both health and disease.
The primary function of DEF6 Gene Knockout Cell Lines revolves around providing a platform for studying gene-specific effects on cellular behavior, growth patterns, and signaling cascades. Researchers can utilize these models to elucidate the biological pathways impacted by DEF6, particularly within the contexts of oncogenesis and immune system disorders. Moreover, the knockout phenotype allows for the exploration of compensatory mechanisms and the possibility of novel therapeutic targets by observing alterations in cellular phenotypes post-knockout.
Scientifically, these cell lines hold significant importance in both translational and basic research, facilitating the development of gene therapy approaches and furthering our understanding of diseases where DEF6 is implicated. They serve as an invaluable resource for drug discovery, allowing for high-throughput screening of pharmaceutical compounds and assessment of their efficacy in modulating the signaling pathways associated with DEF6.
Compared to other traditional models, DEF6 Gene Knockout Cell Lines offer enhanced specificity and reproducibility, minimizing off-target effects that are common in chemical inhibitors. This specificity provides researchers with confidence in their experimental outcomes, significantly streamlining the path from discovery to application.
For researchers and clinicians alike, the DEF6 Gene Knockout Cell Lines represent a compelling tool that enhances our ability to decipher complex biological interactions and develop targeted interventions. This innovation is backed by our company’s extensive expertise in gene editing and cell line development, ensuring that our products meet the highest scientific standards while addressing the evolving needs of the biomedical research community.
Please note that all services are for research use only. Not intended for any clinical use.
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