Gene: DDIT4
Official Full Name: DNA damage inducible transcript 4provided by HGNC
Gene Summary: Predicted to enable 14-3-3 protein binding activity. Involved in negative regulation of TOR signaling and response to hypoxia. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01343 | DDIT4 Knockout cell line (HeLa) | Human | DDIT4 | 1:3~1:6 | Negative | Online Inquiry |
KO10376 | DDIT4 Knockout cell line (HCT 116) | Human | DDIT4 | 1:2~1:4 | Negative | Online Inquiry |
KO10377 | DDIT4 Knockout cell line (HEK293) | Human | DDIT4 | 1:3~1:6 | Negative | Online Inquiry |
KO10378 | DDIT4 Knockout cell line (A549) | Human | DDIT4 | 1:3~1:4 | Negative | Online Inquiry |
DDIT4 Gene Knockout Cell Lines are genetically engineered cell lines in which the DDIT4 gene, implicated in stress responses and cellular metabolism, has been selectively disrupted. This innovative product enables researchers to study the functional consequences of DDIT4 loss, providing a powerful tool for investigating its role in various physiological and pathological processes, including cancer progression, metabolic disorders, and cellular stress responses.
The key mechanism of action involves the complete deletions of the DDIT4 gene, leading to diminished expression of its protein product. This action disrupts normal cellular signaling pathways, particularly the mTOR pathway, which is critical for nutrient sensing, cell growth, and survival. By utilizing DDIT4 knockout cell lines, scientists gain insights into how cells adapt to stressors such as hypoxia or nutrient deprivation, thereby enhancing understanding of homeostatic mechanisms that may be dysfunctional in disease states.
The scientific importance of DDIT4 Gene Knockout Cell Lines lies in their applicability across various research domains, including cancer biology, neurobiology, and metabolic syndrome studies. These cell lines facilitate exploration of gene function in vitro, offering robust models that can be used for drug screening or the identification of novel therapeutic targets.
Compared to traditional cell lines, the DDIT4 Gene Knockout Cell Lines provide a specific and precise tool for elucidating gene function without the confounding effects of unaltered genetic backgrounds. This specificity greatly enhances experimental design, leading to more reliable and reproducible results.
Researchers and clinicians will find exceptional value in the DDIT4 Gene Knockout Cell Lines for their ability to generate targeted insights into the molecular underpinnings of disease. Additionally, our commitment to quality ensures that each cell line undergoes rigorous validation, providing users with confidence in the reliability of their experimental outcomes. Our expertise in biological products and our dedication to advancing research make us a trusted partner in your quest for scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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