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CTSZ Knockout Cell Lines

Gene: CTSZ

Official Full Name: cathepsin Zprovided by HGNC

Gene Summary: The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38345 CTSZ Knockout cell line (HeLa) Human CTSZ 1:3~1:6 Negative Online Inquiry
KO38346 CTSZ Knockout cell line (HCT 116) Human CTSZ 1:2~1:4 Negative Online Inquiry
KO38347 CTSZ Knockout cell line (HEK293) Human CTSZ 1:3~1:6 Negative Online Inquiry
KO38348 CTSZ Knockout cell line (A549) Human CTSZ 1:3~1:4 Negative Online Inquiry

Background

CTSZ Gene Knockout Cell Lines are genetically engineered cell lines created through the targeted disruption of the cathepsin Z (CTSZ) gene, a crucial component in various cellular functions including protein degradation, immune response modulation, and tissue remodeling. These knockout models serve as vital tools for researchers seeking to elucidate the multifaceted roles of CTSZ in both physiological and pathological states.

The primary function of these cell lines lies in their ability to provide insights into the consequences of CTSZ deficiency. By employing CRISPR-Cas9 technology or other gene-editing platforms, researchers have successfully knocked out the CTSZ gene, allowing for the investigation of the gene's role in processes such as inflammation, cancer progression, and neurodegenerative disorders. The resultant phenotypic changes offer a deeper understanding of cellular mechanisms, paving the way for potential therapeutic targets.

The scientific importance of CTSZ Gene Knockout Cell Lines extends to both basic research and clinical applications. For instance, studies have demonstrated that reduced CTSZ expression is associated with altered immune responses, making these cell lines invaluable in immunology research. Furthermore, they provide a robust platform for drug screening and biomarker discovery, enhancing translational research efforts aimed at developing novel therapies.

Compared to alternative models, CTSZ Gene Knockout Cell Lines offer distinct advantages such as enhanced specificity, reproducibility, and the ability to closely mimic human disease conditions. Unlike general knockdowns, which may lead to off-target effects, these knockout cell lines provide a cleaner experimental setup, facilitating more reliable data collection and interpretation.

For researchers, clinicians, and biopharmaceutical companies, these cell lines represent a powerful asset in the quest to uncover the complexities of CTSZ-related pathways and their implications for human health. Our company specializes in high-quality genetic models, with a commitment to supporting scientific advancements through innovative cellular tools. By choosing CTSZ Gene Knockout Cell Lines, users align themselves with a leading provider dedicated to excellence in biotechnology and genetic research applications.

Please note that all services are for research use only. Not intended for any clinical use.

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