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CTNNB1 Knockout Cell Lines

Gene: CTNNB1

Official Full Name: catenin beta 1provided by HGNC

Gene Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00074 CTNNB1 Knockout cell line (HCT 116) Human CTNNB1 1:2~1:4 Negative Online Inquiry
KO00244 CTNNB1 Knockout cell line (HEK293) Human CTNNB1 1:3~1:6 Negative Online Inquiry
KO01334 CTNNB1 Knockout cell line (HeLa) Human CTNNB1 1:3~1:6 Negative Online Inquiry
KO11807 CTNNB1 Knockout cell line (HCT 116) Human CTNNB1 1:2~1:4 Negative Online Inquiry
KO11808 CTNNB1 Knockout cell line (A549) Human CTNNB1 1:3~1:4 Negative Online Inquiry

Background

CTNNB1 Gene Knockout Cell Lines are specialized cell lines engineered to exhibit a complete loss of function of the CTNNB1 gene, which encodes β-catenin, a crucial mediator in the Wnt signaling pathway. This product serves as an invaluable tool for investigating the role of β-catenin in various biological processes, including cell proliferation, differentiation, and apoptosis, particularly in the context of cancer and developmental biology.

These cell lines are created using advanced CRISPR-Cas9 gene editing techniques, ensuring precise and efficient knockout of the CTNNB1 gene. By removing the influence of β-catenin, researchers can study the resulting phenotypic changes and elucidate the molecular mechanisms underlying its involvement in tumorigenesis and other diseases. The ability to analyze these alterations in a controlled environment significantly enhances our understanding of cellular pathways and provides insights into potential therapeutic targets.

The importance of CTNNB1 Gene Knockout Cell Lines in scientific research is underscored by their wide range of applications. In cancer research, for instance, they are instrumental in exploring how the dysregulation of the Wnt/β-catenin pathway contributes to specific tumor types. Furthermore, in clinical settings, these models can aid in screening potential drug candidates and testing novel therapeutic approaches that may target β-catenin-mediated pathways.

What sets our CTNNB1 Gene Knockout Cell Lines apart from alternatives on the market is their superior efficiency and the robustness of results produced. Our meticulously characterized cell lines come with comprehensive data regarding their stability and reproducibility across different experimental conditions, minimizing variability and enhancing experimental precision.

Ultimately, the value of CTNNB1 Gene Knockout Cell Lines lies in their ability to provide researchers and clinicians with a reliable platform to advance the field of molecular biology and therapeutic development. By leveraging our expertise in genetic engineering and cell line development, our company is committed to delivering high-quality products that empower researchers to advance their scientific inquiries with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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