Gene: CRKL
Official Full Name: CRK like proto-oncogene, adaptor proteinprovided by HGNC
Gene Summary: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10885 | CRKL Knockout cell line (HeLa) | Human | CRKL | 1:3~1:6 | Negative | Online Inquiry |
KO10886 | CRKL Knockout cell line (HCT 116) | Human | CRKL | 1:2~1:4 | Negative | Online Inquiry |
KO10887 | CRKL Knockout cell line (HEK293) | Human | CRKL | 1:3~1:6 | Negative | Online Inquiry |
CRKL Gene Knockout Cell Lines are genetically modified cell lines in which the CRKL gene has been specifically inactivated or "knocked out." This product serves as a crucial tool for researchers investigating the role of the CRKL gene in various biological processes, including cell growth, differentiation, and response to extracellular signals. By providing a controlled environment to study these cellular mechanisms, these knockout cell lines facilitate a deeper understanding of the implications of CRKL in health and disease.
The CRKL protein is an adaptor molecule that plays a pivotal role in several signaling pathways, particularly those involved in cellular proliferation and migration. By utilizing these knockout cell lines, researchers can elucidate the gene's specific contributions to oncogenic processes and tumor progression, as CRKL has been implicated in various cancers. The knockout mechanism allows for precise examination of phenotypic changes and functional outcomes, providing insights into cellular behavior in pathological conditions.
The scientific importance of CRKL Gene Knockout Cell Lines extends to translational research, where they can be utilized to screen potential therapeutics or to investigate the efficacy of existing treatments on CRKL-deficient cells. Their application in functional studies enhances the understanding of targeted gene functions, making them invaluable in both academic research and clinical settings.
Compared to traditional genetic manipulation methods, CRKL Gene Knockout Cell Lines offer a more efficient and reliable platform for studying gene function without the variability introduced by transient transfection methods. The established knockout lines ensure consistent biological responses, enhancing reproducibility in experimental results.
For researchers and clinicians focused on cancer biology, signal transduction, and other areas of molecular biology, CRKL Gene Knockout Cell Lines represent an indispensable asset. Their usage can lead to significant insights that may ultimately contribute to the development of targeted therapies and improved patient outcomes.
Our company specializes in providing high-quality biological products and modifications to meet the evolving needs of the scientific community. With a commitment to excellence, we ensure our CRKL Gene Knockout Cell Lines come with detailed characterization and support, empowering users to achieve their research goals with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.