Home / COL25A1 Knockout Cell Lines

COL25A1 Knockout Cell Lines

Gene: COL25A1

Official Full Name: collagen type XXV alpha 1 chainprovided by HGNC

Gene Summary: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07041 COL25A1 Knockout cell line (HeLa) Human COL25A1 1:3~1:6 Negative Online Inquiry
KO07042 COL25A1 Knockout cell line (HEK293) Human COL25A1 1:3~1:6 Negative Online Inquiry

Background

COL25A1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the COL25A1 gene, which encodes for the collagen type XXV alpha 1 chain. This gene plays a pivotal role in various biological processes, including tissue development and integrity, making these knockout cell lines invaluable tools for studying the functional consequences of COL25A1 loss. The mechanisms behind these cell lines involve the use of advanced genetic engineering techniques such as CRISPR/Cas9, ensuring precise ablation of the target gene and enabling researchers to elucidate the pathways and phenotypic changes associated with its disruption.

The scientific importance of COL25A1 Gene Knockout Cell Lines cannot be overstated, as they serve critical functions in both basic and applied research. In clinical settings, understanding the role of COL25A1 has implications in diseases characterized by extracellular matrix dysregulation, including certain fibrotic conditions and cancers. By leveraging these knockout cell lines, researchers can investigate cellular behaviors, signaling pathways, and potential therapeutic interventions that could ameliorate or prevent disease progression.

Unlike traditional gene editing methods, which may yield heterogeneous cell populations, our knockout cell lines offer homogeneity and reproducibility, thus providing more reliable data essential for advancing research. Additionally, their ready-to-use nature saves significant time and resources compared to creating new knockout models from scratch. Researchers and clinicians can also benefit from the ease of use in various experimental setups, from drug screening to cellular assays, making these cell lines a versatile addition to any laboratory.

Our expertise in genetic engineering and commitment to advancing biological research ensure that COL25A1 Gene Knockout Cell Lines are of the highest quality and reliability, helping you to unlock new discoveries in your work. By choosing our product, you are investing in a resource that enhances the efficiency and efficacy of your research efforts in understanding the complexities of gene function in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.