Gene: CLMN
Official Full Name: calminprovided by HGNC
Gene Summary: Predicted to enable actin filament binding activity. Predicted to be involved in negative regulation of cell population proliferation and nuclear migration. Predicted to act upstream of or within neuron projection development. Predicted to be located in membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in cytoplasm and nuclear outer membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18662 | CLMN Knockout cell line (HCT 116) | Human | CLMN | 1:2~1:4 | Negative | Online Inquiry |
KO18663 | CLMN Knockout cell line (HEK293) | Human | CLMN | 1:3~1:6 | Negative | Online Inquiry |
KO18664 | CLMN Knockout cell line (A549) | Human | CLMN | 1:3~1:4 | Negative | Online Inquiry |
CLMN Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the CLMN gene, which encodes the protein calmin, involved in cellular processes such as cytoskeletal organization and cellular signaling. These knockout cell lines are invaluable tools for researchers seeking to understand the functional roles of the CLMN gene and its protein products in various physiological and pathological contexts.
The primary mechanism by which CLMN Gene Knockout Cell Lines function is through targeted gene disruption, typically achieved via CRISPR/Cas9 or RNA interference techniques. By eliminating the expression of the CLMN gene, researchers can explore downstream signaling pathways, assess cellular responses to stress, and examine implications in disease models, particularly those linked to muscle degeneration or neurological disorders. This mechanistic insight aids in developing therapeutic strategies and advancing our understanding of gene function in health and disease.
The scientific importance of these knockout cell lines cannot be overstated. They provide a unique platform for investigating gene function in dynamic cellular environments, facilitating breakthroughs in both fundamental research and applied biomedical contexts. For instance, they can be instrumental in drug discovery processes and in elucidating the role of calmin in muscle biology, a significant area for therapeutic interventions in muscular dystrophies.
Compared to conventional cell lines, CLMN Gene Knockout Cell Lines offer specific advantages, including the ability to observe the effects of gene loss in real-time and elucidate compensatory mechanisms that may otherwise confound results. This high specificity reduces variability and enhances experimental reproducibility, leading to more reliable data.
For researchers and clinicians, the value of CLMN Gene Knockout Cell Lines lies in their capacity to enable precise manipulation of the cellular environment, thereby enhancing experimental outcomes and expanding the range of possible applications. The insights gained through this product can inform potential clinical strategies and pave the way for innovative treatments.
Our company specializes in providing high-quality biological products with a strong emphasis on precision genetics and cell line development, ensuring that our customers have access to state-of-the-art tools, such as the CLMN Gene Knockout Cell Lines, to advance their research and contribute to scientific progress.
Please note that all services are for research use only. Not intended for any clinical use.
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