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CLIP3 Knockout Cell Lines

Gene: CLIP3

Official Full Name: CAP-Gly domain containing linker protein 3provided by HGNC

Gene Summary: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28505 CLIP3 Knockout cell line (HEK293) Human CLIP3 1:3~1:6 Negative Online Inquiry

Background

CLIP3 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the CLIP3 gene, known to play a critical role in cellular functions, including signal transduction and cytoskeletal dynamics. These cell lines are generated using advanced CRISPR/Cas9 technology, which precisely disrupts the CLIP3 gene, enabling researchers to evaluate the gene's contributions to various biological processes and disease mechanisms.

The primary mechanism by which CLIP3 Gene Knockout Cell Lines function is through the selective elimination of the CLIP3 gene's expression. This knockout allows for the investigation of downstream signaling pathways and phenotypic changes that occur in response to the absence of CLIP3. By using these cell lines, researchers can explore cellular behaviors such as migration, adhesion, and response to environmental stressors, which are vital in understanding diseases, particularly cancer and neurodegenerative disorders.

The scientific significance of CLIP3 Gene Knockout Cell Lines extends into both research and clinical settings. These models serve as vital tools for dissecting the molecular underpinnings of diseases linked to CLIP3 dysfunction, allowing scientists to screen for potential therapeutic targets and validate drug efficacy in a controlled environment. Furthermore, their application can streamline the development of targeted therapies, enhancing translational research outcomes.

One of the key advantages of CLIP3 Gene Knockout Cell Lines over traditional models is their specificity and precision. Unlike conventional methods that may yield heterogeneous results, these cell lines provide consistent, reproducible data, essential for robust scientific inquiry. Additionally, the versatility of these cell lines allows for application in a variety of assays, including gene expression analysis, protein interaction studies, and drug response evaluations.

This product holds immense value for researchers and clinicians keen on deepening their understanding of the molecular biology central to the CLIP3 gene's function. With access to such specialized research tools, users can accelerate their discoveries and innovation in therapeutic approaches.

Our company prides itself on delivering high-quality biological products that empower researchers. With a strong foundation in genetic engineering technologies, we ensure that our offerings, including CLIP3 Gene Knockout Cell Lines, adhere to the highest standards of quality and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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