CLCF1 Knockout Cell Lines

Gene: CLCF1

Official Full Name: cardiotrophin like cytokine factor 1provided by HGNC

Gene Summary: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO29192	CLCF1 Knockout cell line (HeLa)	Human	CLCF1	1:3~1:6	Negative	Online Inquiry
KO29193	CLCF1 Knockout cell line (HCT 116)	Human	CLCF1	1:2~1:4	Negative	Online Inquiry
KO29194	CLCF1 Knockout cell line (A549)	Human	CLCF1	1:3~1:4	Negative	Online Inquiry

Background

CLCF1 Gene Knockout Cell Lines are meticulously engineered cell lines that have had the CLCF1 gene specifically disrupted or “knocked out.” This genetic modification allows researchers to study the functional roles of the CLCF1 protein, which is implicated in critical biological processes, including neurodevelopment and immune system regulation. By eliminating the expression of CLCF1, these cell lines provide a unique experimental platform to dissect the signaling pathways and cellular mechanisms influenced by this factor.

The primary mechanism of action for CLCF1 knockouts involves the alteration of various intracellular pathways that are dependent on this protein. Researchers can observe changes in cellular behavior, such as proliferation, apoptosis, or differentiation, thereby elucidating the role of CLCF1 in both normal physiology and disease states. This capability is particularly valuable in fields like neurobiology and immunology, where understanding signaling mechanisms can inform the development of targeted therapies.

The scientific importance of CLCF1 Gene Knockout Cell Lines extends into both basic research and clinical applications, offering insights into diseases such as schizophrenia, cancer, and autoimmune conditions. The ability to model these diseases in vitro presents a powerful tool for drug screening and therapeutic interventions.

When compared to other gene knockout strategies, CLCF1 Gene Knockout Cell Lines stand out for their specificity and ease of use. Unlike traditional methods that may deliver off-target effects, our cell lines guarantee precise genetic alterations, ensuring reproducibility and reliability in experimental outcomes.

For researchers and clinicians seeking to deepen their understanding of CLCF1's role in health and disease, these cell lines are an invaluable asset. With our commitment to quality and innovation, our company brings unparalleled expertise in producing high-fidelity biological products that empower scientific discoveries and advance clinical research.

Please note that all services are for research use only. Not intended for any clinical use.

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