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CIC Knockout Cell Lines

Gene: CIC

Official Full Name: capicua transcriptional repressorprovided by HGNC

Gene Summary: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05440 CIC Knockout cell line (HeLa) Human CIC 1:3~1:6 Negative Online Inquiry
KO05441 CIC Knockout cell line (HCT 116) Human CIC 1:2~1:4 Negative Online Inquiry
KO05442 CIC Knockout cell line (HEK293) Human CIC 1:3~1:6 Negative Online Inquiry
KO05443 CIC Knockout cell line (A549) Human CIC 1:3~1:4 Negative Online Inquiry

Background

CIC Gene Knockout Cell Lines are genetically engineered cellular models that have had the CIC gene selectively disrupted. This allows researchers to study the functional consequences of the absence of this gene, which is implicated in various biological processes and diseases, including certain cancers and developmental disorders. Utilizing CRISPR-Cas9 technology, these cell lines provide a precise and efficient method for performing gene knockout experiments.

The key function of CIC Gene Knockout Cell Lines lies in their ability to elucidate the role of the CIC gene in cellular pathways and physiological conditions. These cell lines facilitate investigations into how CIC regulates gene expression, cellular proliferation, and differentiation, thereby providing vital insights into both normal and pathological states. The mechanism of action is predicated on the loss of CIC function, leading to observable phenotypic changes that can be quantitatively or qualitatively assessed by researchers.

In terms of scientific importance, these cell lines are invaluable for both research and clinical applications. They serve as a powerful tool for functional genomics, drug development, and therapeutic target validation. Their use accelerates the understanding of CIC’s contribution to tumorigenesis and its potential as a biomarker for clinical diagnostics and prognostics.

Compared to alternative models such as wild-type cell lines or traditional knockdown methods, CIC Gene Knockout Cell Lines offer superior specificity and confidence in results due to complete gene inactivation rather than partial or transient expression changes. This results in more reproducible and interpretable data, elevating overall research quality.

For researchers, clinicians, and pharmaceutical companies, investing in CIC Gene Knockout Cell Lines means leveraging an advanced tool to deepen biological understanding and enhance the efficiency of drug discovery processes. Our company has a longstanding commitment to advancing genetic research, and our offering of these knockout cell lines embodies our expertise in molecular biology and genetic engineering, contributing to groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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