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CDX2 Knockout Cell Lines

Gene: CDX2

Official Full Name: caudal type homeobox 2provided by HGNC

Gene Summary: This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01567 CDX2 Knockout cell line (HeLa) Human CDX2 1:3~1:6 Negative Online Inquiry
KO01568 CDX2 Knockout cell line (HCT 116) Human CDX2 1:2~1:4 Negative Online Inquiry
KO01569 CDX2 Knockout cell line (HEK293) Human CDX2 1:3~1:6 Negative Online Inquiry

Background

CDX2 Gene Knockout Cell Lines are specially engineered cell lines in which the CDX2 gene has been functionally disrupted. CDX2, a crucial transcription factor, plays a significant role in the development and differentiation of intestinal epithelial cells. By creating knockout models, researchers can explore the essential functions of CDX2 in cellular processes, including tissue regeneration, differentiation, and the etiology of gastrointestinal diseases. The mechanism behind these cell lines involves the precise use of CRISPR-Cas9 technology or similar genome-editing tools that allow for targeted gene inactivation, providing researchers with a robust platform for studying gene functions in a controlled environment.

The scientific importance of CDX2 Gene Knockout Cell Lines extends to their applications in both basic biological and biomedical research. These cell lines are invaluable for investigating the role of CDX2 in intestinal development, function, and pathology, particularly in relation to diseases such as colorectal cancer and other gastrointestinal disorders. By elucidating the roles of transcription factors like CDX2, researchers can develop targeted therapies and improve clinical outcomes.

Compared to traditional gene knockout methods, our CDX2 Gene Knockout Cell Lines offer higher efficiency and precision of gene disruption, reduced off-target effects, and a straightforward user protocol that simplifies experimental workflows. With the ability to generate stable cell lines that mimic a tissue-specific environment, these products stand out as highly reliable tools in the molecular biology toolkit.

For researchers and clinicians focused on gastrointestinal biology, these cell lines represent a significant advancement, offering essential insights into CDX2's contributions to health and disease. Our commitment to excellence in genomic engineering and cutting-edge biotechnologies ensures that you receive products of the highest quality, aiding in the advancement of your scientific endeavors. With years of expertise in providing tailored solutions in the realm of biological research, we are dedicated to empowering your discoveries with our innovative offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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