Gene: CD74
Official Full Name: CD74 moleculeprovided by HGNC
Gene Summary: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09947 | CD74 Knockout cell line (HeLa) | Human | CD74 | 1:3~1:6 | Negative | Online Inquiry |
CD74 Gene Knockout Cell Lines are an innovative tool for investigating the biological functions of the CD74 gene, known to play a crucial role in various physiological and pathological processes, including immune response and cancer progression. These cell lines have been genetically modified to permanently disrupt the expression of the CD74 gene, enabling researchers to analyze its downstream effects on cellular activities and signaling pathways.
The primary function of CD74, also known as the invariant chain, is to facilitate antigen presentation by MHC class II molecules. By utilizing these knockout cell lines, researchers can dissect the role of CD74 in immune regulation, explore its interactions with other proteins, and study the impacts of its absence on cellular proliferation, differentiation, and apoptosis. This allows for a deeper understanding of diseases linked to CD74 dysregulation, such as certain autoimmune disorders and malignancies.
Scientifically, CD74 Gene Knockout Cell Lines hold significant importance in both fundamental and applied research. In clinical contexts, these lines can be pivotal for developing targeted therapies aimed at modulating immune responses or inhibiting tumor growth in CD74-overexpressing cancers. Moreover, they open avenues for pharmaceutical testing and biomarker discovery, enhancing our knowledge of disease mechanisms.
What distinguishes our CD74 Gene Knockout Cell Lines from alternatives on the market is the precision of our gene-editing protocols, ensuring high efficiency and reproducibility in knockout validation. Additionally, these cell lines are accompanied by comprehensive technical support, including detailed user manuals and troubleshooting advice, which facilitates seamless integration into existing research workflows.
For researchers and clinicians seeking to explore the multifaceted roles of CD74, these knockout cell lines are invaluable. They offer a rigorous platform for experimentation that can yield insights critical for advancing therapeutic strategies. At [Company Name], we specialize in providing high-quality biological products tailored to meet the evolving needs of the research community, driven by a commitment to innovation and scientific excellence.
Please note that all services are for research use only. Not intended for any clinical use.
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