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CCN1 Knockout Cell Lines

Gene: CCN1

Official Full Name: cellular communication network factor 1provided by HGNC

Gene Summary: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04273 CCN1 Knockout cell line (HeLa) Human CCN1 1:3~1:6 Negative Online Inquiry
KO04274 CCN1 Knockout cell line (HCT 116) Human CCN1 1:2~1:4 Negative Online Inquiry
KO04275 CCN1 Knockout cell line (HEK293) Human CCN1 1:3~1:6 Negative Online Inquiry
KO04276 CCN1 Knockout cell line (A549) Human CCN1 1:3~1:4 Negative Online Inquiry

Background

CCN1 Gene Knockout Cell Lines are advanced biological tools designed for the functional study of the CCN1 gene, which encodes the connective tissue growth factor (CTGF). This gene plays crucial roles in various biological processes, including cell proliferation, apoptosis, and extracellular matrix production. By employing CRISPR/Cas9 gene editing technology to create these knockout cell lines, researchers can effectively disrupt the expression of the CCN1 gene, allowing for the investigation of its specific biological functions and contributions to disease models.

The primary function of CCN1 Gene Knockout Cell Lines is to facilitate the detailed examination of cellular pathways impacted by the absence of functional CCN1 protein. With the knockout model, scientists can elucidate the gene's role in fibrotic diseases, tumorigenesis, and wound healing, among other conditions. This can lead to a deeper understanding of underlying mechanisms and potentially highlight novel therapeutic targets.

In research and clinical settings, the scientific importance of these cell lines is evident, as they enable the development of innovative strategies in regenerative medicine and cancer research. Unlike traditional cell lines, which may express CCN1 at varying levels, the knockout models ensure a consistent genetic background, providing greater reproducibility of results.

One distinct advantage of the CCN1 Gene Knockout Cell Lines lies in their ability to save time and resources while offering robust experimental frameworks. Compared to alternatives such as RNA interference or overexpression systems, gene knockout approaches generally produce more reliable data regarding loss-of-function studies, thereby accelerating the pace of discovery.

Researchers, clinicians, and pharmaceutical developers will find these cell lines invaluable for their potential to uncover novel insights into CCN1-related pathologies and therapeutic interventions. Leveraging our expertise in cellular biology and gene editing, our company is proud to offer these state-of-the-art CCN1 Gene Knockout Cell Lines, ensuring that your research stands at the forefront of innovation in biological studies.

Please note that all services are for research use only. Not intended for any clinical use.

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