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CAPN5 Knockout Cell Lines

Gene: CAPN5

Official Full Name: calpain 5provided by HGNC

Gene Summary: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38746 CAPN5 Knockout cell line (HCT 116) Human CAPN5 1:2~1:4 Negative Online Inquiry
KO38747 CAPN5 Knockout cell line (HEK293) Human CAPN5 1:3~1:6 Negative Online Inquiry
KO38748 CAPN5 Knockout cell line (A549) Human CAPN5 1:3~1:4 Negative Online Inquiry

Background

CAPN5 Gene Knockout Cell Lines are a revolutionary tool in molecular biology designed to facilitate the in-depth study of calpain-5, a member of the calpain family of cysteine proteases. This product comprises genetically engineered cell lines in which the CAPN5 gene has been specifically disrupted, allowing researchers to investigate the roles and regulatory mechanisms of calpain-5 in various cellular processes. By using CRISPR-Cas9 technology for precise gene editing, these cell lines provide a reliable platform for studying the effects of gene knockout on cell functionality and signaling pathways.

The primary function of CAPN5 Gene Knockout Cell Lines lies in their ability to serve as a model to elucidate the physiological and pathological roles of calpain-5 in muscle development, immune response, and signal transduction. As calpain-5 is associated with processes such as apoptosis and the modulation of protein turnover, the knockout cell lines enable researchers to explore therapeutic avenues for diseases linked to dysregulated calpain activity, including certain cancers and muscular dystrophies.

In terms of scientific importance, these cell lines have vast applications in both research and clinical settings. They can be utilized to screen for potential therapeutic agents that restore normal function in calpain-related disorders or serve as a controlled model to better understand the complexities of calpain-mediated signaling in various tissues.

CAPN5 Gene Knockout Cell Lines stand out from alternative products due to their high specificity and the ease of use they offer in experimental design. Unlike traditional methods that rely on chemical inhibitors or transient knockdowns, our knockout cell lines provide a stable and long-lasting solution for studying gene functions and their consequential biological effects.

For researchers and clinicians, the CAPN5 Gene Knockout Cell Lines offer immense value. They facilitate breakthroughs in understanding calpain biology, thus paving the way for innovative treatment strategies. Our commitment to excellence and innovation is backed by our extensive experience in developing high-quality biological products, ensuring that researchers have the best tools to advance their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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